2013
Role of Gap Junctions and Hemichannels in Parasitic Infections
Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. Role of Gap Junctions and Hemichannels in Parasitic Infections. BioMed Research International 2013, 2013: 589130. PMID: 24236292, PMCID: PMC3819887, DOI: 10.1155/2013/589130.Peer-Reviewed Original ResearchConceptsForm gap junction channelsCell-cell interfaceDiverse physiologic processesGap junction channelsInvertebrate cellsVertebratesJunction channelsRole of CxsCell surfaceNew therapeutic designsPanx channelsHemichannelsGap junctionsTherapeutic designCellular communicationRecent findingsParasitic infectionsPhysiologic processesPathological statesPossible roleCxRecent evidenceInnexinsChannel typesPannexins
2012
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels
Orellana J, Sánchez H, Schalper K, Figueroa V, Sáez J. Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels. Advances In Experimental Medicine And Biology 2012, 740: 777-794. PMID: 22453969, DOI: 10.1007/978-94-007-2888-2_34.Peer-Reviewed Original ResearchConceptsGap junction channelsConnexin-based channelsExtra-cellular milieuNumerous cellular eventsCell-cell interactionsMembrane proteinsMolecular basisCellular eventsIntercellular communicationJunction channelsRole of Ca2ConnexinsIntercellular calciumHemichannelsIntercellular propagationIntercellular Ca2RegulationCalcium wavesCalcium interactionCa2ProteinPathwayInteractionFamilyModulation of gap junction channels and hemichannels by growth factors
Schalper K, Riquelme M, Brañes M, Martínez A, Vega J, Berthoud V, Bennett M, Sáez J. Modulation of gap junction channels and hemichannels by growth factors. Molecular Omics 2012, 8: 685-698. PMID: 22218428, DOI: 10.1039/c1mb05294b.Peer-Reviewed Original ResearchConceptsGap junction channelsTransduction pathwaysGrowth factor signal transduction pathwaysJunction channelsNumerous cellular processesCell-cell communicationCell-cell channelsGrowth factorSignal transduction pathwaysProtein kinase-dependent mechanismNormal cellular responseCellular transduction pathwaysKinase-dependent mechanismCell membrane receptorsGap junction hemichannelsCellular coordinationCellular processesProtein kinaseCellular responsesCell stageMembrane receptorsMembrane channelsCell typesFunctional consequencesChannel insertion
2010
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Sáez J, Schalper K, Retamal M, Orellana J, Shoji K, Bennett M. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Experimental Cell Research 2010, 316: 2377-2389. PMID: 20595004, DOI: 10.1016/j.yexcr.2010.05.026.Peer-Reviewed Original ResearchConceptsCell membrane permeabilityMembrane permeabilityComplex signaling cascadesConnexin hemichannelsDiverse cell typesCx HCsGap junction channelsVertebrate cellsCell membrane permeabilizationForm hemichannelsMembrane permeabilizationSignaling cascadesOpen probabilityJunction channelsCell typesCultured cellsExtracellular microenvironmentCell membraneHemichannelsMost cellsLow open probabilityStage dependencyUnitary conductanceSmall moleculesConnexins
2009
Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration
Orellana JA, Sáez PJ, Shoji KF, Schalper KA, Palacios–Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC. Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration. Antioxidants & Redox Signaling 2009, 11: 369-399. PMID: 18816186, PMCID: PMC2713807, DOI: 10.1089/ars.2008.2130.Peer-Reviewed Original ResearchConceptsGap junction channelsJunction channelsDiverse cell typesPro-inflammatory agentsAcute inflammatory responseActivity of hemichannelsGap junctional communicationGlial hemichannelsProtein subunitsCx43 hemichannel activityGlial activationAnomalous proteinInflammatory processMembrane channelsCell typesNeuronal viabilityInflammatory responseNeuronal Cx36Astroglial networksNormal brainHemichannel activityChannel disordersHemichannelsSubthreshold stimulationATP release