2012
Modulation of gap junction channels and hemichannels by growth factors
Schalper K, Riquelme M, Brañes M, Martínez A, Vega J, Berthoud V, Bennett M, Sáez J. Modulation of gap junction channels and hemichannels by growth factors. Molecular Omics 2012, 8: 685-698. PMID: 22218428, DOI: 10.1039/c1mb05294b.Peer-Reviewed Original ResearchConceptsGap junction channelsTransduction pathwaysGrowth factor signal transduction pathwaysJunction channelsNumerous cellular processesCell-cell communicationCell-cell channelsGrowth factorSignal transduction pathwaysProtein kinase-dependent mechanismNormal cellular responseCellular transduction pathwaysKinase-dependent mechanismCell membrane receptorsGap junction hemichannelsCellular coordinationCellular processesProtein kinaseCellular responsesCell stageMembrane receptorsMembrane channelsCell typesFunctional consequencesChannel insertion
2009
Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration
Orellana JA, Sáez PJ, Shoji KF, Schalper KA, Palacios–Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC. Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration. Antioxidants & Redox Signaling 2009, 11: 369-399. PMID: 18816186, PMCID: PMC2713807, DOI: 10.1089/ars.2008.2130.Peer-Reviewed Original ResearchConceptsGap junction channelsJunction channelsDiverse cell typesPro-inflammatory agentsAcute inflammatory responseActivity of hemichannelsGap junctional communicationGlial hemichannelsProtein subunitsCx43 hemichannel activityGlial activationAnomalous proteinInflammatory processMembrane channelsCell typesNeuronal viabilityInflammatory responseNeuronal Cx36Astroglial networksNormal brainHemichannel activityChannel disordersHemichannelsSubthreshold stimulationATP release