2014
Possible role of hemichannels in cancer
Schalper KA, Carvajal-Hausdorf D, Oyarzo MP. Possible role of hemichannels in cancer. Frontiers In Physiology 2014, 5: 237. PMID: 25018732, PMCID: PMC4073485, DOI: 10.3389/fphys.2014.00237.Peer-Reviewed Original ResearchDiverse cell processesPost-translational eventsCell proliferationPossible roleTumor suppressorMembrane transportInvolvement of hemichannelsHemichannelsCell processesCancer cellsCurrent technical limitationsTumor progressionTumor growthProliferationCellsPannexinsNeoplastic cellsSuppressorPanxsRoleConnexinsImmune responseProteinTechnical limitations
2013
Role of Gap Junctions and Hemichannels in Parasitic Infections
Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. Role of Gap Junctions and Hemichannels in Parasitic Infections. BioMed Research International 2013, 2013: 589130. PMID: 24236292, PMCID: PMC3819887, DOI: 10.1155/2013/589130.Peer-Reviewed Original ResearchConceptsForm gap junction channelsCell-cell interfaceDiverse physiologic processesGap junction channelsInvertebrate cellsVertebratesJunction channelsRole of CxsCell surfaceNew therapeutic designsPanx channelsHemichannelsGap junctionsTherapeutic designCellular communicationRecent findingsParasitic infectionsPhysiologic processesPathological statesPossible roleCxRecent evidenceInnexinsChannel typesPannexins
2009
Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.
Schalper K, Orellana J, Berthoud V, Sáez J. Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Current Vascular Pharmacology 2009, 7: 486-505. PMID: 19485891, DOI: 10.2174/157016109789043937.Peer-Reviewed Original ResearchConceptsHuman genetic diseasesNormal cell functioningHemichannel activityMost cell typesConnexin mutantsForm homoTransmembrane proteinMembrane permeabilizationPlasma membraneLethal stimuliMembrane pathwaysCell functioningHuman diseasesCell deathCell typesGenetic diseasesMost cellsHemichannelsPannexinsSmall moleculesConnexinsTransportersPathological conditionsPathwayVertebrates
2008
Currently Used Methods for Identification and Characterization of Hemichannels
Schalper K, Palacios-Prado N, Orellana J, Sáez J. Currently Used Methods for Identification and Characterization of Hemichannels. Cell Communication & Adhesion 2008, 15: 207-218. PMID: 18649191, DOI: 10.1080/15419060802014198.Peer-Reviewed Original ResearchConceptsVertebrate cellsMammalian cellsTransmembrane proteinPlasma membraneFunctional hemichannelsMolecular identityPannexin hemichannelsConnexin hemichannelsHemichannelsCommunication pathwaysSmall moleculesConnexinsNew experimental approachExperimental approachCellsPannexinsBulk of informationProteinIdentificationPathwayParacrineMembraneVivoResponseFurther studies