2024
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2015
Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Sanmamed MF, Rodriguez I, Schalper KA, Oñate C, Azpilikueta A, Rodriguez-Ruiz ME, Morales-Kastresana A, Labiano S, Pérez-Gracia JL, Martín-Algarra S, Alfaro C, Mazzolini G, Sarno F, Hidalgo M, Korman AJ, Jure-Kunkel M, Melero I. Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice. Cancer Research 2015, 75: 3466-3478. PMID: 26113085, DOI: 10.1158/0008-5472.can-14-3510.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalColorectal NeoplasmsDNA-Binding ProteinsGraft vs Host DiseaseHT29 CellsHumansInterleukin Receptor Common gamma SubunitLeukocytes, MononuclearLymphocyte ActivationMiceNivolumabProgrammed Cell Death 1 ReceptorT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 9ConceptsPeripheral blood mononuclear cellsT lymphocytesHuman T lymphocytesAllogeneic human peripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsT cell-mediated diseaseImmune checkpoint drugsImmunostimulatory monoclonal antibodiesCell-mediated diseaseRegulatory T lymphocytesHumanized murine modelBlood mononuclear cellsHumanized mouse modelPreclinical model systemsLymphocyte infiltrationTherapeutic regimenMononuclear cellsCell surface expressionCancer immunologyGastric carcinomaImmunodeficient miceMurine modelMouse modelSame patientTumor xenografts