2012
Oral Chemotherapeutic Agents
Ogita S, LoRusso P, Li J. Oral Chemotherapeutic Agents. 2012, 1-37. DOI: 10.1002/9780470921920.edm132.Peer-Reviewed Original ResearchOral chemotherapeutic agentsInterindividual pharmacokinetic variabilityChemotherapeutic agentsPharmacokinetic variabilityImmune-modulating agentsTraditional cytotoxic agentsFirst-pass metabolismClass of agentsCytochrome P450 3A4Mechanism of actionAntiacid medicationOral agentsConcomitant administrationIntestinal effluxHormonal agentsIntravenous agentsFood effectDrug dispositionABCB1 transporterDrug resistanceClinical useCytotoxic agentsStaff time savingsP450 3A4Noninvasive administration
2004
The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer
El-Rayes B, LoRusso P. The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer. American Journal Of Cancer 2004, 3: 369-375. DOI: 10.2165/00024669-200403060-00004.Peer-Reviewed Original ResearchBreast cancerZoledronic acidPamidronic acidIbandronic acidPlacebo-controlled trialSerum creatinine levelsSpinal cord compressionLarge randomized studiesMetastatic breast cancerRole of bisphosphonatesBreast cancer patientsClodronic acidClass of agentsCord compressionGastrointestinal symptomsRenal impairmentSkeletal complicationsSkeletal eventsCreatinine levelsMajor toxicityBone destructionBone metastasesRadiographic evidenceRandomized studySignificant morbidity
1995
Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents
Corbett T, Valeriote F, Lorusso P, Polin L, Panchapor C, Pugh S, White K, Knight J, Demchik L, Jones J, Jones L, Lowichik N, Biernat L, Foster B, Wozniak A, Lisow L, Valdivieso M, Baker L, Leopold W, Sebolt J, Bissery M, Mattes K, Dzubow J, Rake J, Perni R, Wentland M, Coughlin S, Shaw J, Liversidge G, Liversidge E, Bruno J, Sarpotdar P, Moore R, Patterson G. Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents. Pharmaceutical Biology 1995, 33: 102-122. DOI: 10.3109/13880209509067092.Peer-Reviewed Original ResearchSCID miceNude miceTumor modelHuman tumorsHuman tumor xenograft modelsUnique histologic appearanceXenograft model systemAthymic nude miceHuman tumor modelsUnique biologic entityTumor xenograft modelClass of agentsNormal cellsDrug response profilesActivity testingTumor takeSolid tumor cellsVariety of agentsClinical trialsBiologic behaviorHistologic appearanceNew agentsXenograft modelSingle tumorSolid tumors