2008
Enzastaurin, an Oral Serine/Threonine Kinase Inhibitor, As Second- or Third-Line Therapy of Non–Small-Cell Lung Cancer
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G. Enzastaurin, an Oral Serine/Threonine Kinase Inhibitor, As Second- or Third-Line Therapy of Non–Small-Cell Lung Cancer. Journal Of Clinical Oncology 2008, 26: 1135-1141. PMID: 18309949, DOI: 10.1200/jco.2007.14.3685.Peer-Reviewed Original ResearchConceptsOral serine/threonine kinase inhibitorCell lung cancerPFS ratesMetastatic NSCLCOverall survivalLung cancerEastern Cooperative Oncology Group performance statusSix-month PFS rateProgression-free survival ratesEpidermal growth factor inhibitorsSerine/threonine kinase inhibitorProtein kinase CKinase inhibitorsPrior systemic regimensMedian overall survivalPrimary end pointThird-line therapyPhase II trialGrowth factor inhibitorsTumor cell apoptosisMedian PFSStable diseaseCommon toxicitiesPrior therapySystemic regimens
2007
Enzastaurin, a Protein Kinase Cβ–Selective Inhibitor, and Its Potential Application as an Anticancer Agent in Lung Cancer
Herbst RS, Oh Y, Wagle A, Lahn M. Enzastaurin, a Protein Kinase Cβ–Selective Inhibitor, and Its Potential Application as an Anticancer Agent in Lung Cancer. Clinical Cancer Research 2007, 13: 4641s-4646s. PMID: 17671157, DOI: 10.1158/1078-0432.ccr-07-0538.Peer-Reviewed Original ResearchConceptsSerine/threonine kinase inhibitorLung cancerOral serine/threonine kinase inhibitorProtein kinase CFavorable safety profileCurrent phase IKinase CTumor cell apoptosisAkt pathwayClinical findingsSafety profilePKC inhibitorTumor-induced angiogenesisPreclinical experienceCell apoptosisEnzastaurinKinase inhibitorsPhase ICancerA phase II study of enzastaurin as second- or third-line treatment of non-small cell lung cancer (NSCLC)
Bepler G, Oh Y, Burris H, Cleverly A, Lahn M, Herbst R. A phase II study of enzastaurin as second- or third-line treatment of non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2007, 25: 7543-7543. DOI: 10.1200/jco.2007.25.18_suppl.7543.Peer-Reviewed Original ResearchNon-small cell lung cancerProgression-free survivalThird-line treatmentStable diseaseOverall survivalOral serine/threonine kinase inhibitorMedian progression-free survivalMulticenter phase II trialPrior platinum-based chemotherapyDays of discontinuationMedian overall survivalObjective tumor responsePhase II studyPhase II trialPlatinum-based chemotherapyCell lung cancerWeeks of enrollmentPI3K/Akt pathwayPI3K/AktTumor cell apoptosisOral enzastaurinPFS ratesCommon toxicitiesPrior therapyII study