1990
The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function
Herbst RS, Pelletier M, Boczko EM, Babiss LE. The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function. Journal Of Virology 1990, 64: 161-172. PMID: 2136708, PMCID: PMC249075, DOI: 10.1128/jvi.64.1.161-172.1990.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus Early ProteinsAdenoviruses, HumanAnimalsBase SequenceCell DifferentiationCell LineCell NucleusDNA-Binding ProteinsEnhancer Elements, GeneticGene ExpressionGene Expression Regulation, ViralGenes, ViralHeLa CellsHumansMolecular Sequence DataMutationOncogene Proteins, ViralPromoter Regions, GeneticRNA, MessengerSuppression, GeneticTranscription, GeneticViral Structural ProteinsConceptsE1A gene transcriptionFetal fibroblast cellsGene transcriptionHepatoma cell lineFibroblast cellsCell phenotypeCell linesLiver hepatocytesRodent hepatocytesRat liver hepatocytesSimilar binding activityFurther suppressionHeLa cellsEnhancer elementsCellsBinding activityHepatocytesViral genomeDifferentiated cellsE1A enhancerNegative regulationCellular differentiationImportant mechanismPhenotypeHigh levelsCis effect of the type 5 adenovirus E1A gene enhancer element on cellular transformation
Herbst R, Pelletier M, Babiss L. Cis effect of the type 5 adenovirus E1A gene enhancer element on cellular transformation. Journal Of Cellular Biochemistry 1990, 42: 33-44. PMID: 2137130, DOI: 10.1002/jcb.240420104.Peer-Reviewed Original ResearchConceptsCREF cellsViral DNA replicationDNA replicationWild-type virusEnhancer elementsGene enhancer elementsRodent embryo fibroblastsCis effectViral DNA integrationE1A gene expressionE1A mRNAsCytoplasmic mRNA levelsE1B mRNAsDNA template concentrationCellular transformationGene expressionDNA integrationViral E1AEmbryo fibroblastsType 5 adenovirusMutant virusMRNA levelsMRNACellsMRNA concentrations
1988
Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein
Herbst RS, Hermo H, Fisher PB, Babiss LE. Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein. Journal Of Virology 1988, 62: 4634-4643. PMID: 2972843, PMCID: PMC253576, DOI: 10.1128/jvi.62.12.4634-4643.1988.Peer-Reviewed Original ResearchConceptsE1A 289R proteinViral early gene expressionCellular gene expressionGene expressionE1A proteinsEarly gene expressionRat embryo fibroblast cellsEnhancer-dependent transcriptionViral E1A proteinsE1A gene productsAltered cell growthEmbryo fibroblast cellsTranscription initiationProtein functionCommon pathwayCellular transformationCREF cellsE1A 13SGene productsGene promoterFoci formationViral genomeHeLa cellsCell growthType 5 adenovirus