2016
Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer
McLaughlin J, Han G, Schalper KA, Carvajal-Hausdorf D, Pelakanou V, Rehman J, Velcheti V, Herbst R, LoRusso P, Rimm DL. Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer. JAMA Oncology 2016, 2: 1-9. PMID: 26562159, PMCID: PMC4941982, DOI: 10.1001/jamaoncol.2015.3638.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, MonoclonalAntibody SpecificityB7-H1 AntigenBiomarkers, TumorCarcinoma, Non-Small-Cell LungFemaleFluorescent Antibody TechniqueHumansImmunohistochemistryLung NeoplasmsMaleObserver VariationPredictive Value of TestsReproducibility of ResultsRetrospective StudiesTissue Array AnalysisConceptsTumor-infiltrating lymphocytesPD-L1 expressionPD-L1 antibodiesPD-L1 protein expressionCell lung cancerPD-L1Whole tissue sectionsQuantitative immunofluorescenceLung cancerChromogenic immunohistochemistryPoor concordanceDifferent PD-L1 antibodiesHigh tumor-infiltrating lymphocytesTumor PD-L1 expressionPD-L1 protein levelsCell lung cancer biopsiesMonoclonal antibodiesCurrent consensus guidelinesProtein expressionDurable clinical responsesMain outcome measuresEarly phase trialsLung cancer biopsiesRabbit monoclonal antibodyCorresponding tissue microarrays
1984
Tyrosine hydroxylase-immunoreactive neurons of the hypothalamus: A light and electron microscopic study
van den Pol AN, Herbst RS, Powell JF. Tyrosine hydroxylase-immunoreactive neurons of the hypothalamus: A light and electron microscopic study. Neuroscience 1984, 13: 1117-1156. PMID: 6152034, DOI: 10.1016/0306-4522(84)90292-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody SpecificityAxonsDendritesDopamineHypothalamusImmunoenzyme TechniquesRatsSynaptic TransmissionTyrosine 3-MonooxygenaseConceptsImmunoreactive cellsCell groupsAdjacent cell groupsHypothalamic groupParaventricular nucleusDendritic arborsTyrosine hydroxylaseTyrosine hydroxylase-immunoreactive neuronsTyrosine hydroxylase-like immunoreactivityImmunoreactive cell groupsLarge immunoreactive cellsVentral lateral hypothalamusHydroxylase-immunoreactive neuronsTyrosine hydroxylase immunoreactivityHydroxylase-like immunoreactivityPosterior hypothalamic regionMorphology of neuronsMicrons coronal sectionsImmunoreactive groupsSomatic appendagesDendritic overlapHydroxylase immunoreactivityVentromedial nucleusAnterior hypothalamusLateral hypothalamus