2023
Precise, pragmatic and inclusive: the modern era of oncology clinical trials
Grant M, Goldberg S. Precise, pragmatic and inclusive: the modern era of oncology clinical trials. Nature Medicine 2023, 29: 1908-1909. PMID: 37524954, DOI: 10.1038/s41591-023-02466-6.Peer-Reviewed Original Research
2021
Management of Brain Metastases
Collier E, Chiang V, Goldberg S. Management of Brain Metastases. Current Cancer Research 2021, 115-137. DOI: 10.1007/978-3-030-74028-3_6.Peer-Reviewed Original ResearchBrain metastasesSystemic therapyLocal therapyAsymptomatic brain metastasesNew systemic therapiesSource of morbidityInclusion of patientsMalignant brain tumorsQuality of lifeNew cancer treatmentsSignificant morbidityWorse prognosisPatient survivalCNS diseaseLung cancerClinical trialsBrain tumorsMetastasisNSCLCTherapyCancer treatmentSmall molecule drugsFrequent originMorbidityTreatment
2014
1327P A Phase I Open-Label Study to Evaluate the Safety and Tolerability of Medi4736, an Anti-Programmed Cell Death-Ligand 1(Pd-L1) Antibody, in Combination with Tremelimumab in Patients with Advanced Non-Small Cell Lung Cancer (Nsclc)
Antonia S, Goldberg S, Balmanoukian A, Narwal R, Robbins P, D'Angelo G, Blake-Haskins A, Karakunnel J, Rizvi N. 1327P A Phase I Open-Label Study to Evaluate the Safety and Tolerability of Medi4736, an Anti-Programmed Cell Death-Ligand 1(Pd-L1) Antibody, in Combination with Tremelimumab in Patients with Advanced Non-Small Cell Lung Cancer (Nsclc). Annals Of Oncology 2014, 25: iv466. DOI: 10.1093/annonc/mdu349.106.Peer-Reviewed Original ResearchStock/stock optionsDrug-related AEsClinical trialsAdvanced non-small cell lung cancerT-lymphocyte-associated protein 4Non-small cell lung cancerCurrent safety profileDose-expansion phaseSafety/tolerabilityAntitumor activityHuman IgG2 monoclonal antibodyDose-escalation phasePhase 1 studyImmune cell phenotypesCell lung cancerCell death 1Cell death ligandPD-L1 bindingGreater antitumor activityAnti-tumor activityT cell activationHuman IgG1 mAbBoehringer Ingelheim PharmaceuticalsCohort 1aECOG PS