2022
Multicenter analysis of stereotactic radiosurgery for multiple brain metastases from EGFR and ALK driven non-small cell lung cancer
Wandrey N, Gao D, Robin T, Contessa J, Singh C, Chiang V, Li J, Chen A, Wang Y, Sheehan J, Dutta S, Weiss S, Paly J, Rusthoven C. Multicenter analysis of stereotactic radiosurgery for multiple brain metastases from EGFR and ALK driven non-small cell lung cancer. Lung Cancer 2022, 176: 144-148. PMID: 36641932, PMCID: PMC10552603, DOI: 10.1016/j.lungcan.2022.11.019.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerOverall survivalCell lung cancerStereotactic radiosurgeryBrain metastasesMultivariable adjustmentMulticenter analysisLung cancerNext-generation tyrosine kinase inhibitorsSRS treatmentOnly negative prognostic factorWhole brain radiotherapyMedian overall survivalMultiple brain metastasesNegative prognostic factorFavorable overall survivalTyrosine kinase inhibitorsTreatment 1CNS progressionMulticenter outcomesMedian followPrognostic factorsFavorable prognosisCNS diseaseTreatment optionsBrain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer
Adua S, Arnal-Estapé A, Zhao M, Qi B, Liu Z, Kravitz C, Hulme H, Strittmatter N, López-Giráldez F, Chande S, Albert A, Melnick M, Hu B, Politi K, Chiang V, Colclough N, Goodwin R, Cross D, Smith P, Nguyen D. Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer. Nature Communications 2022, 13: 7690. PMID: 36509758, PMCID: PMC9744876, DOI: 10.1038/s41467-022-34889-z.Peer-Reviewed Original ResearchConceptsGene expression programsRas homolog family member ACancer cellsFamily member AEpidermal growth factor receptorExpression programsMetastatic cancer cellsSRF signalingGrowth factor receptorTumor microenvironmentLung cancerFunctional linkExtracellular lamininDrug-resistant cancer cellsMutant non-small cell lung cancerNon-small cell lung cancerCentral nervous system relapseMolecular studiesMember AEGFR-mutant lung cancerFactor receptorNervous system relapseCell lung cancerDisseminated tumor cellsBrain tumor microenvironment
2020
MRI-Guided Laser Interstitial Thermal Therapy for Radiation Necrosis in Previously Irradiated Brain Arteriovenous Malformations
Hong CS, Cord BJ, Kundishora AJ, Elsamadicy AA, Beckta JM, Huttner A, Chiang VL, Matouk CC. MRI-Guided Laser Interstitial Thermal Therapy for Radiation Necrosis in Previously Irradiated Brain Arteriovenous Malformations. Practical Radiation Oncology 2020, 10: e298-e303. PMID: 32068154, DOI: 10.1016/j.prro.2020.02.003.Peer-Reviewed Original Research
2019
Prognosticating brain tumor patient survival after laser thermotherapy: Comparison between neuroradiological reading and semi-quantitative analysis of MRI data
Hanna JM, Temares D, Hyder F, Rothman DL, Fulbright RK, Chiang VL, Coman D. Prognosticating brain tumor patient survival after laser thermotherapy: Comparison between neuroradiological reading and semi-quantitative analysis of MRI data. Magnetic Resonance Imaging 2019, 65: 45-54. PMID: 31675529, DOI: 10.1016/j.mri.2019.09.011.Peer-Reviewed Original Research
2015
Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases?
Colaco RJ, Martin P, Kluger HM, Yu JB, Chiang VL. Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases? Journal Of Neurosurgery 2015, 125: 17-23. PMID: 26544782, DOI: 10.3171/2015.6.jns142763.Peer-Reviewed Original ResearchConceptsTreatment-related imaging changesCytotoxic chemotherapyRadiation necrosisBrain metastasesSystemic therapyStereotactic Gamma Knife radiosurgeryMedian overall survivalGamma knife radiosurgeryHigh-dose radiationChemotherapy eraGK surgeryImmunotherapy increasesMedian followConclusions PatientsOverall survivalImaging changesGK treatmentKnife radiosurgeryInflammatory reactionStereotactic radiosurgeryLower riskRadiosurgical treatmentPatientsImmunotherapyTherapySurgery in neuro-oncolgy with a focus on stereotactic radiosurgery
Chiang V. Surgery in neuro-oncolgy with a focus on stereotactic radiosurgery. CNS Oncology 2015, 4: 199-201. PMID: 26118857, PMCID: PMC6088336, DOI: 10.2217/cns.15.18.Peer-Reviewed Original Research
2014
Radiologic and histologic consequences of radiosurgery for brain tumors
Alomari A, Rauch PJ, Orsaria M, Minja FJ, Chiang VL, Vortmeyer AO. Radiologic and histologic consequences of radiosurgery for brain tumors. Journal Of Neuro-Oncology 2014, 117: 33-42. PMID: 24442402, DOI: 10.1007/s11060-014-1359-8.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryNon-enhancing regionsNon-enhancing areasRecurrent tumorsEncephalopathic changesBrain lesionsRecurrent tumor growthMalignant brain lesionsGadolinium-enhanced MRIHigh clinical relevanceDemyelinating changesSeparate biopsiesNon-enhancing componentsInflammatory demyelinationRadiological changesHistologic consequencesImaging changesReactive astrocytosisHistopathological changesKnife radiosurgeryPathological changesCoagulative necrosisBrain tumorsClinical relevanceHistological results
2013
Role of stereotactic radiosurgery in patients with more than four brain metastases
Jairam V, Chiang V, Yu JB, Knisely J. Role of stereotactic radiosurgery in patients with more than four brain metastases. CNS Oncology 2013, 2: 181-193. PMID: 24273642, PMCID: PMC3835313, DOI: 10.2217/cns.13.4.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyBrain metastasesStereotactic radiosurgeryIntracranial relapseUse of SRSFirst-line therapyFirst-line treatmentNeurocognitive side effectsTreatment of patientsMultiple small dosesUndetected metastasesMedical CenterRadiation therapyHigh doseInstitutional trialsSide effectsPatientsMetastasisWhole brainSmall dosesTarget volumeEarly dementiaMemory lossRadiation treatmentRelapse
2012
Management of Brain Metastases Surgery, Radiation, or Both?
Patel TR, Knisely JP, Chiang VL. Management of Brain Metastases Surgery, Radiation, or Both? Hematology/Oncology Clinics Of North America 2012, 26: 933-947. PMID: 22794291, DOI: 10.1016/j.hoc.2012.04.008.Peer-Reviewed Original Research
2011
Delayed Radiation-Induced Vasculitic Leukoencephalopathy
Rauch PJ, Park HS, Knisely JP, Chiang VL, Vortmeyer AO. Delayed Radiation-Induced Vasculitic Leukoencephalopathy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 369-375. PMID: 22024206, DOI: 10.1016/j.ijrobp.2011.06.1982.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryKnife radiosurgeryRadiation therapyYale-New Haven HospitalRadiation-induced leukoencephalopathyHigh-dose radiation fieldT cell infiltrationMetastatic brain cancerFocused radiation therapyMedium-sized vesselsNew Haven HospitalActive vasculitisLeukoencephalopathic changesVasculitic componentBrain metastasesVascular sclerosisNeuropathologic examinationSignificant morbiditySurgical managementTumor recurrencePathological evidenceHistopathologic observationsLeukoencephalopathyPathological differencesBrain cancerNon-rigid Registration of Longitudinal Brain Tumor Treatment MRI
Chitphakdithai N, Chiang VL, Duncan JS. Non-rigid Registration of Longitudinal Brain Tumor Treatment MRI. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2011, 2011: 4893-4896. PMID: 22255435, PMCID: PMC3753806, DOI: 10.1109/iembs.2011.6091212.Peer-Reviewed Original Research
2010
Radiosurgery alone for 5 or more brain metastases: expert opinion survey.
Knisely JP, Yamamoto M, Gross CP, Castrucci WA, Jokura H, Chiang VL. Radiosurgery alone for 5 or more brain metastases: expert opinion survey. Journal Of Neurosurgery 2010, 113 Suppl: 84-9. PMID: 21121790, DOI: 10.3171/2010.8.gks10999.Peer-Reviewed Original ResearchConceptsKarnofsky Performance Scale scoreBrain metastasesPerformance Scale scoreStereotactic radiosurgeryClinical factorsScale scoreUse of SRSMore brain metastasesOligometastatic brain metastasesInternational Stereotactic Radiosurgery SocietySystemic disease controlFinal study sampleCharacteristics of physiciansMetastasis locationPatient characteristicsInitial treatmentPhysician characteristicsUnivariate analysisMedian numberClinician's approachMetastasisSRS outcomesSan FranciscoMultivariate analysisDisease control
2005
Interventional Neuroradiology Adjuncts and Alternatives in Patients with Head and Neck Vascular Lesions
Johnson MH, Chiang VL, Ross DA. Interventional Neuroradiology Adjuncts and Alternatives in Patients with Head and Neck Vascular Lesions. Neurosurgery Clinics Of North America 2005, 16: 547-560. PMID: 15990044, DOI: 10.1016/j.nec.2005.04.007.Peer-Reviewed Original ResearchConceptsEndovascular techniquesVascular lesionsEndovascular transarterial embolizationGroup of patientsNeck vascular lesionsManagement of lesionsIschemic deficitsNeurologic symptomsPreoperative managementTransarterial embolizationSevere headVertebral arteryVascular injuryTolerance testPerioperative settingPatient managementSalvage measureSkull baseTraumatic conditionsVascular structuresLesionsPatientsNeckHeadEmbolization
2000
cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma
Gary S, Zerillo C, Chiang V, Gaw J, Gray G, Hockfield S. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. Gene 2000, 256: 139-147. PMID: 11054543, DOI: 10.1016/s0378-1119(00)00362-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceBrainBrevicanCarrier ProteinsCerebral CortexChondroitin Sulfate ProteoglycansChromosome MappingChromosomes, Human, Pair 1Cloning, MolecularDNA, ComplementaryGene ExpressionGene Expression Regulation, DevelopmentalGene Expression Regulation, NeoplasticGliomaHumansLectins, C-TypeMolecular Sequence DataNerve Tissue ProteinsProtein IsoformsProteoglycansRNATranscription, GeneticConceptsBEHAB/brevicanHuman gliomasChondroitin sulfate proteoglycanNormal adult cortexBrain-specific proteoglycanNormal human cortexBrain-specific memberAdult cortexCortical developmentRNase protection analysisGliomasHuman cortexNormal levelsBrain developmentLow levelsLectican familyExtracellular matrixBrevicanSpecific proteoglycansSulfate proteoglycanHuman brainCortexMiceFull-length isoformUniformly low level