2022
Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids
Cheng LY, Dai P, Wu LR, Patel AA, Zhang DY. Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids. IScience 2022, 25: 105046. PMID: 36147958, PMCID: PMC9486625, DOI: 10.1016/j.isci.2022.105046.Peer-Reviewed Original ResearchDNA populationsNext-generation sequencingLimitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics
Song P, Wu LR, Yan YH, Zhang JX, Chu T, Kwong LN, Patel AA, Zhang DY. Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics. Nature Biomedical Engineering 2022, 6: 232-245. PMID: 35102279, PMCID: PMC9336539, DOI: 10.1038/s41551-021-00837-3.Peer-Reviewed Original Research
2012
Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing
Narayan A, Carriero NJ, Gettinger SN, Kluytenaar J, Kozak KR, Yock TI, Muscato NE, Ugarelli P, Decker RH, Patel AA. Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing. Cancer Research 2012, 72: 3492-3498. PMID: 22581825, PMCID: PMC3426449, DOI: 10.1158/0008-5472.can-11-4037.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerTumor DNATumor DNA levelsCell lung cancerCell-free tumor DNATreatment-associated changesDNA levelsTumor-specific mutationsPractical diagnostic testLung cancerPractical clinical implementationPatient samplesDiagnostic testsHotspot mutationsClinical implementationNext-generation sequencingBloodCancer biomarkersSuccessful useNormal DNAMutationsPatientsDeep sequencing