2024
Central nervous system metastases in advanced non-small cell lung cancer: A review of the therapeutic landscape
Weller M, Remon J, Rieken S, Vollmuth P, Ahn M, Minniti G, Le Rhun E, Westphal M, Brastianos P, Soo R, Kirkpatrick J, Goldberg S, Öhrling K, Hegi-Johnson F, Hendriks L. Central nervous system metastases in advanced non-small cell lung cancer: A review of the therapeutic landscape. Cancer Treatment Reviews 2024, 130: 102807. PMID: 39151281, DOI: 10.1016/j.ctrv.2024.102807.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced non-small cell lung cancerCentral nervous system metastasesCentral nervous systemCell lung cancerOncogene-addicted non-small cell lung cancerLung cancerAssessment of treatment responseProgressive CNS metastasesImmune checkpoint inhibitorsNervous system metastasesLocal treatment optionsMultimodal therapeutic strategiesCNS diseaseSubgroup of patientsTreatment of patientsCheckpoint inhibitorsCNS metastasesLung cancer clinical trialsSystemic metastasesLocal therapySystemic therapyIntracranial activityTargeted therapyTreatment options
2023
Brief Report: Safety and Antitumor Activity of Durvalumab Plus Tremelimumab in Programmed Cell Death-(Ligand)1–Monotherapy Pretreated, Advanced NSCLC: Results From a Phase 1b Clinical Trial
Garon E, Spira A, Goldberg S, Chaft J, Papadimitrakopoulou V, Cascone T, Antonia S, Brahmer J, Camidge D, Powderly J, Wozniak A, Felip E, Wu S, Ascierto M, Elgeioushi N, Awad M. Brief Report: Safety and Antitumor Activity of Durvalumab Plus Tremelimumab in Programmed Cell Death-(Ligand)1–Monotherapy Pretreated, Advanced NSCLC: Results From a Phase 1b Clinical Trial. Journal Of Thoracic Oncology 2023, 18: 1094-1102. PMID: 37146752, DOI: 10.1016/j.jtho.2023.04.020.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerObjective response rateAdvanced non-small cell lung cancerTreatment-related adverse eventsBlinded independent central reviewIndependent central reviewRECIST v1.1Refractory patientsAdverse eventsCentral reviewRefractory non-small cell lung cancerCommon treatment-related adverse eventsSolid Tumors version 1.1Cell death protein 1End pointPhase 1b clinical trialEfficacy of durvalumabPhase 1b studyManageable safety profilePrimary end pointSecondary end pointsProgression-free survivalResponse Evaluation CriteriaMonths of treatmentDeath protein 1
2021
1239P ORCHARD osimertinib + savolitinib interim analysis: A biomarker-directed phase II platform study in patients (pts) with advanced non-small cell lung cancer (NSCLC) whose disease has progressed on first-line (1L) osimertinib
Yu H, Ambrose H, Baik C, Cho B, Cocco E, Goldberg S, Goldman J, Kraljevic S, de Langen A, Okamoto I, Piotrowska Z, Pluta M, Powar S, Aransay N, Riess J, Le X. 1239P ORCHARD osimertinib + savolitinib interim analysis: A biomarker-directed phase II platform study in patients (pts) with advanced non-small cell lung cancer (NSCLC) whose disease has progressed on first-line (1L) osimertinib. Annals Of Oncology 2021, 32: s978-s979. DOI: 10.1016/j.annonc.2021.08.1844.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced non-small cell lung cancerCell lung cancerFirst-line osimertinibLung cancerInterim analysisPatientsOsimertinibCancerDiseaseAdoption of consolidative durvalumab among patients with locally advanced non-small cell lung cancer.
Jairam V, Pasha S, Soulos P, Goldberg S, Yu J, Decker R, Gross C, Park H. Adoption of consolidative durvalumab among patients with locally advanced non-small cell lung cancer. Journal Of Clinical Oncology 2021, 39: e20550-e20550. DOI: 10.1200/jco.2021.39.15_suppl.e20550.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerTumor characteristicsLung cancerFDA approvalConsolidative durvalumabPatient characteristicsUnresectable stage III non-small cell lung cancerStage III non-small cell lung cancerAdvanced non-small cell lung cancerFirst-line platinum-doublet chemotherapyStudy periodFlatiron Health databasePlatinum-doublet chemotherapyGuideline-concordant carePD-L1 statusMultivariable logistic regressionCochran-Armitage testDe-identified databaseChi-square testDefinitive chemoradiationDoublet chemotherapyEligible patientsPACIFIC trialSurgery details
2020
Comparative efficacy of chemoimmunotherapy versus immunotherapy alone in the front-line treatment of advanced non-small cell lung cancer: A systematic review and network meta-analysis.
Pathak R, Lopes G, Yu H, Ji W, Aryal M, Frumento K, Wallis C, Klaassen Z, Park H, Goldberg S. Comparative efficacy of chemoimmunotherapy versus immunotherapy alone in the front-line treatment of advanced non-small cell lung cancer: A systematic review and network meta-analysis. Journal Of Clinical Oncology 2020, 38: 9552-9552. DOI: 10.1200/jco.2020.38.15_suppl.9552.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsIpi/nivoPD-1 axis inhibitorsPD-L1 1Phase 3 RCTsPD-L1 statusPD-L1Advanced non-small cell lung cancerSingle-agent immune checkpoint inhibitorsSystematic reviewCombination immune checkpoint inhibitorsNon-small cell lung cancerDual checkpoint blockadeCTLA-4 inhibitorsFront-line treatmentCell lung cancerSignificant differencesAdvanced NSCLCICI monotherapyOS benefitCheckpoint inhibitorsProspective trialCheckpoint blockadeCombination chemotherapyNSCLC patients
2015
Tumor response from durvalumab (MEDI4736) + tremelimumab treatment in patients with advanced non-small cell lung cancer (NSCLC) is observed regardless of PD-L1 status
Rizvi N, Chaft J, Balmanoukian A, Goldberg S, Sanborn R, Steele K, Rebelatto M, Gu Y, Karakunnel J, Antonia S. Tumor response from durvalumab (MEDI4736) + tremelimumab treatment in patients with advanced non-small cell lung cancer (NSCLC) is observed regardless of PD-L1 status. Journal For ImmunoTherapy Of Cancer 2015, 3: p193. PMCID: PMC4649434, DOI: 10.1186/2051-1426-3-s2-p193.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced non-small cell lung cancerPD-L1 statusCell lung cancerLung cancerDurvalumabPatientsCancer
2014
1327P A Phase I Open-Label Study to Evaluate the Safety and Tolerability of Medi4736, an Anti-Programmed Cell Death-Ligand 1(Pd-L1) Antibody, in Combination with Tremelimumab in Patients with Advanced Non-Small Cell Lung Cancer (Nsclc)
Antonia S, Goldberg S, Balmanoukian A, Narwal R, Robbins P, D'Angelo G, Blake-Haskins A, Karakunnel J, Rizvi N. 1327P A Phase I Open-Label Study to Evaluate the Safety and Tolerability of Medi4736, an Anti-Programmed Cell Death-Ligand 1(Pd-L1) Antibody, in Combination with Tremelimumab in Patients with Advanced Non-Small Cell Lung Cancer (Nsclc). Annals Of Oncology 2014, 25: iv466. DOI: 10.1093/annonc/mdu349.106.Peer-Reviewed Original ResearchStock/stock optionsDrug-related AEsClinical trialsAdvanced non-small cell lung cancerT-lymphocyte-associated protein 4Non-small cell lung cancerCurrent safety profileDose-expansion phaseSafety/tolerabilityAntitumor activityHuman IgG2 monoclonal antibodyDose-escalation phasePhase 1 studyImmune cell phenotypesCell lung cancerCell death 1Cell death ligandPD-L1 bindingGreater antitumor activityAnti-tumor activityT cell activationHuman IgG1 mAbBoehringer Ingelheim PharmaceuticalsCohort 1aECOG PSA multicenter randomized phase II trial of erlotinib with and without hydroxychloroquine (HCQ) in TKI-naive patients (pts) with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC).
Neal J, Wakelee H, Feliciano J, Goldberg S, Morgensztern D, Das M, Heist R, Lennes I, Muzikansky A, Edelman M, Gettinger S, Sequist L. A multicenter randomized phase II trial of erlotinib with and without hydroxychloroquine (HCQ) in TKI-naive patients (pts) with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2014, 32: 8088-8088. DOI: 10.1200/jco.2014.32.15_suppl.8088.Peer-Reviewed Original ResearchA phase 1b open-label study to evaluate the safety and tolerability of MEDI4736, an anti–PD-L1 antibody, in combination with tremelimumab in subjects with advanced non–small cell lung cancer.
Pinder M, Rizvi N, Goldberg S, Balmanoukian A, Narwal R, Robbins P, D'Angelo G, Blake-Haskins A, Karakunnel J, Antonia S. A phase 1b open-label study to evaluate the safety and tolerability of MEDI4736, an anti–PD-L1 antibody, in combination with tremelimumab in subjects with advanced non–small cell lung cancer. Journal Of Clinical Oncology 2014, 32: e19137-e19137. DOI: 10.1200/jco.2014.32.15_suppl.e19137.Peer-Reviewed Original Research
2012
Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR -mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance.
Heon S, Nishino M, Goldberg S, Porter J, Sequist L, Jackman D, Johnson B. Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR -mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance. Journal Of Clinical Oncology 2012, 30: 7525-7525. DOI: 10.1200/jco.2012.30.15_suppl.7525.Peer-Reviewed Original ResearchNon-small cell lung cancerDrug-free intervalAdvanced non-small cell lung cancerEGFR-TKIEGFR mutationsMedian PFSMutant non-small cell lung cancerEGFR-mutant non-small cell lung cancerEGFR-mutant advanced non-small cell lung cancerSingle-agent gefitinibObjective tumor responseCell lung cancerSensitizing EGFR mutationsEGFR T790MNSCLC ptsRECIST 1.1Systemic regimensProspective trialMedian intervalRetrospective studyLung cancerTumor responseFree intervalPIK3CA mutationsRadiographic assessment