2023
Selected-Lesion Stereotactic Radiosurgery in Treatment of Patients with Multiple Brain Metastases: A Single Institution Retrospective Study
Mange A, Singh C, Theriault B, Hansen J, An Y, Aneja S, Chiang V. Selected-Lesion Stereotactic Radiosurgery in Treatment of Patients with Multiple Brain Metastases: A Single Institution Retrospective Study. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e135. DOI: 10.1016/j.ijrobp.2023.06.939.Peer-Reviewed Original ResearchMultiple brain metastasesBrain metastasesStereotactic radiosurgeryMedian KPSCommon indicationTumor characteristicsClinical trialsSRS treatmentSingle-institution retrospective studySubsequent-line treatmentMethods Clinical dataPatient selection criteriaTreatment of patientsSubset of lesionsNumber of lesionsDiagnosis of melanomaCNS progressionCNS radiationPrior WBRTOverall survivalPalliative treatmentPatient characteristicsProgressive diseaseImmunotherapy trialsSurvival groupLocal Control and Survival Outcomes After Stereotactic Radiosurgery for Brain Metastases From Gastrointestinal Primaries: An International Multicenter Analysis
Singh R, Bowden G, Mathieu D, Perlow H, Palmer J, Elhamdani S, Shepard M, Liang Y, Nabeel A, Reda W, Tawadros S, Abdelkarim K, El-Shehaby A, Emad R, Elazzazi A, Warnick R, Gozal Y, Daly M, McShane B, Addis-Jackson M, Karthikeyan G, Smith S, Picozzi P, Franzini A, Kaisman-Elbaz T, Yang H, Wei Z, Legarreta A, Hess J, Templeton K, Pikis S, Mantziaris G, Simonova G, Liscak R, Peker S, Samanci Y, Chiang V, Niranjan A, Kersh C, Lee C, Trifiletti D, Lunsford L, Sheehan J. Local Control and Survival Outcomes After Stereotactic Radiosurgery for Brain Metastases From Gastrointestinal Primaries: An International Multicenter Analysis. Neurosurgery 2023, 93: 592-598. PMID: 36942965, DOI: 10.1227/neu.0000000000002456.Peer-Reviewed Original ResearchConceptsKarnofsky performance statusStereotactic radiosurgeryOverall survivalBrain metastasesUnivariate analysisLocal controlGI primaryExtracranial metastasesPrognostic factorsBrain metastases treated with stereotactic radiosurgeryAssociated with inferior LCAssociated with inferior OSMedian Karnofsky performance statusEvaluate potential prognostic factorsInternational multicenter analysisPlanning target volumePotential prognostic factorsKaplan-Meier analysisOne-yearProportional hazards modelInferior LCInferior OSOS ratesLC ratesGastrointestinal primaryEfficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases
Chan M, Tatter S, Chiang V, Fecci P, Strowd R, Prabhu S, Hadjipanayis C, Kirkpatrick J, Sun D, Sinicrope K, Mohammadi A, Sevak P, Abram S, Kim A, Leuthardt E, Chao S, Phillips J, Lacroix M, Williams B, Placantonakis D, Silverman J, Baumgartner J, Piccioni D, Laxton A. Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases. Neuro-Oncology Advances 2023, 5: vdad031. PMID: 37114245, PMCID: PMC10129388, DOI: 10.1093/noajnl/vdad031.Peer-Reviewed Original ResearchLaser interstitial thermal therapyKarnofsky performance statusRadiation necrosisInterstitial thermal therapyBrain metastasesLocal controlMedian Karnofsky performance statusRecurrent brain metastasesMedian hospitalization timeLow patient morbidityLesional progressionMultivariable FineCumulative incidenceOverall survivalPerformance statusSymptom controlHospitalization timeSystemic therapyMedian timeNeurological deathSymptom managementKaplan-MeierPatient morbiditySeizure prevalenceUS Centers
2022
Multicenter analysis of stereotactic radiosurgery for multiple brain metastases from EGFR and ALK driven non-small cell lung cancer
Wandrey N, Gao D, Robin T, Contessa J, Singh C, Chiang V, Li J, Chen A, Wang Y, Sheehan J, Dutta S, Weiss S, Paly J, Rusthoven C. Multicenter analysis of stereotactic radiosurgery for multiple brain metastases from EGFR and ALK driven non-small cell lung cancer. Lung Cancer 2022, 176: 144-148. PMID: 36641932, PMCID: PMC10552603, DOI: 10.1016/j.lungcan.2022.11.019.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerOverall survivalCell lung cancerStereotactic radiosurgeryBrain metastasesMultivariable adjustmentMulticenter analysisLung cancerNext-generation tyrosine kinase inhibitorsSRS treatmentOnly negative prognostic factorWhole brain radiotherapyMedian overall survivalMultiple brain metastasesNegative prognostic factorFavorable overall survivalTyrosine kinase inhibitorsTreatment 1CNS progressionMulticenter outcomesMedian followPrognostic factorsFavorable prognosisCNS diseaseTreatment optionsStereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer.
Kowalchuk R, Niranjan A, Hess J, Antonios J, Zhang M, Braunstein S, Ross R, Pikis S, Deibert C, Lee C, Yang H, Langlois A, Mathieu D, Peker S, Samanci Y, Rusthoven C, Chiang V, Wei Z, Lunsford L, Trifiletti D, Sheehan J. Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer. Journal Of Neurosurgery 2022, 138: 1608-1614. PMID: 36433878, DOI: 10.3171/2022.10.jns221900.Peer-Reviewed Original ResearchTriple-negative breast cancerLocal tumor progressionStereotactic radiosurgeryBreast cancerOverall survivalMetastatic lesionsPerformance statusLocal controlTriple-negative breast cancer metastasisMedian Karnofsky performance statusTumor progressionWhole-brain radiation therapyFavorable performance statusMedian margin dosePrior stereotactic radiosurgerySymptomatic radiation necrosisKarnofsky performance statusIntracranial metastatic diseaseRetrospective chart reviewLocal tumor controlBreast cancer metastasisIntracranial metastatic lesionsMargin doseMultiinstitutional cohortBrain metastasesSURG-23. EFFICACY OF LASER INTERSTITIAL THERMAL THERAPY (LITT) FOR NEWLY DIAGNOSED AND RECURRENT IDH WILD-TYPE GLIOBLASTOMA
de Groot J, Kim A, Prabhu S, Rao G, Laxton A, Fecci P, O'Brien B, Sloan A, Chiang V, Tatter S, Mohammadi A, Placantonakis D, Strowd R, Chen C, Hadjipanayis C, Khasraw M, Sun D, Piccioni D, Sinicrope K, Campian J, Kurz S, Williams B, Smith K, Tovar-Spinoza Z, Leuthardt E. SURG-23. EFFICACY OF LASER INTERSTITIAL THERMAL THERAPY (LITT) FOR NEWLY DIAGNOSED AND RECURRENT IDH WILD-TYPE GLIOBLASTOMA. Neuro-Oncology 2022, 24: vii256-vii257. PMCID: PMC9660753, DOI: 10.1093/neuonc/noac209.989.Peer-Reviewed Original ResearchLaser interstitial thermal therapyIDH wild-type glioblastomaConventional surgical resectionWild-type glioblastomaInterstitial thermal therapySurgical resectionProspective multicenter registryMaximal safe resectionTime of diagnosisGross total resectionPrimary brain tumorsCytoreductive approachMedian OSAdjuvant temozolomideHospital stayMulticenter registryAdverse eventsOverall survivalRecurrent patientsClinical outcomesRecurrent GBMTraditional resectionMedian lengthSurgical approachTreatment options
2021
SURG-02. Stereotactic Laser Ablation (SLA) followed by consolidation stereotactic radiosurgery (SRS) as a treatment strategy for brain metastasis that recurred locally after initial radiosurgery (BMRS): a collaborative institutional experience
Pena-Pino I, Ma J, Hori Y, Fomchenko E, Dusenbery K, Reynolds M, Wilke C, Yuan J, Barnett G, Chiang V, Mohammadi A, Chen C. SURG-02. Stereotactic Laser Ablation (SLA) followed by consolidation stereotactic radiosurgery (SRS) as a treatment strategy for brain metastasis that recurred locally after initial radiosurgery (BMRS): a collaborative institutional experience. Neuro-Oncology Advances 2021, 3: iii23-iii23. PMCID: PMC8351296, DOI: 10.1093/noajnl/vdab071.095.Peer-Reviewed Original ResearchStereotactic laser ablationStereotactic radiosurgeryOverall survivalTreatment strategiesLocal controlDays of SRSSymptomatic radiation necrosisMedian overall survivalSystemic disease progressionRepeat stereotactic radiosurgeryIndependent clinical trialsInitial radiosurgerySteroid therapyBrain metastasesClinical outcomesRadiation necrosisFavorable outcomeClinical trialsDisease progressionFLAIR volumeInstitutional experiencePatientsCE volumeRadiosurgeryLocal failure
2019
RADI-34. USE OF LOW-DOSE STEREOTACTIC RADIOSURGERY FOR ADVANCED BRAIN METASTASES
Yang D, Yu J, Chiang V. RADI-34. USE OF LOW-DOSE STEREOTACTIC RADIOSURGERY FOR ADVANCED BRAIN METASTASES. Neuro-Oncology Advances 2019, 1: i28-i28. PMCID: PMC7213353, DOI: 10.1093/noajnl/vdz014.126.Peer-Reviewed Original ResearchGamma Knife stereotactic radiosurgeryBrain metastasesStereotactic radiosurgeryOverall survivalDisease progressionTime to disease progressionBRAF V600E tumorsMutation-targeted therapiesMedian overall survivalMetastatic melanoma patientsTreat brain metastasesPoor performance statusTumor controlMelanoma patientsSystemic therapyAdvanced diseasePerformance statusRe-treatmentTesticular cancerComposite endpointMetastasisSystemic agentsStudy exitImmunotherapyPatientsMLTI-06. BEVACIZUMAB VERSUS SURGICAL INTERVENTION FOR RADIATION NECROSIS IN PREVIOUSLY IRRADIATED BRAIN METASTASES
Hong C, Sujijantarat N, Chiang V. MLTI-06. BEVACIZUMAB VERSUS SURGICAL INTERVENTION FOR RADIATION NECROSIS IN PREVIOUSLY IRRADIATED BRAIN METASTASES. Neuro-Oncology Advances 2019, 1: i15-i15. PMCID: PMC7213266, DOI: 10.1093/noajnl/vdz014.065.Peer-Reviewed Original ResearchProgression-free survivalLaser interstitial thermal ablationBrain metastasesRadiation necrosisOverall survivalSurgical managementSurgical interventionSingle-institution chart reviewTime of interventionInterstitial thermal ablationBevacizumab cohortGood KPSLower KPSBevacizumab therapySurgery cohortChart reviewMedical managementTrue efficacyBevacizumabComparative outcomesPatientsLesionsComparison groupThermal ablationInterventionSURG-06. LASER INTERSTITIAL THERMAL THERAPY COMPARED TO CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY
Hong C, Deng D, Sujijantarat N, Vera A, Chiang V. SURG-06. LASER INTERSTITIAL THERMAL THERAPY COMPARED TO CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY. Neuro-Oncology Advances 2019, 1: i31-i32. PMCID: PMC7213364, DOI: 10.1093/noajnl/vdz014.141.Peer-Reviewed Original ResearchLaser interstitial thermal therapyProgression-free survivalBrain metastasesRadiation necrosisOverall survivalStereotactic radiosurgeryRecurrent tumorsSingle-institution chart reviewPost-operative salvagePre-operative symptomsSub-group analysisViable alternative treatmentRe-growing tumorSteroid taperNeurological outcomeChart reviewSymptom reliefUnderwent craniotomyTumor lesionsAlternative treatmentCraniotomyLocal controlPatientsMetastasisSmall lesionsRADI-31. MULTI-INSTITUTIONAL VALIDATION OF BRAIN METASTASIS VELOCITY, A RECENTLY DEFINED PREDICTOR OF OUTCOMES FOLLOWING STEREOTACTIC RADIOSURGERY
Chan M, McTyre E, Soike M, Ayala-Peacock D, Hepel J, Page B, Contessa J, Chiang V, Attia A, Braunstein S, Chung C, Ruiz J, Fiveash J, Chao S, Farris M. RADI-31. MULTI-INSTITUTIONAL VALIDATION OF BRAIN METASTASIS VELOCITY, A RECENTLY DEFINED PREDICTOR OF OUTCOMES FOLLOWING STEREOTACTIC RADIOSURGERY. Neuro-Oncology Advances 2019, 1: i28-i28. PMCID: PMC7213264, DOI: 10.1093/noajnl/vdz014.123.Peer-Reviewed Original ResearchBrain metastasis velocityDistant brain failureMedian overall survivalOverall survivalPredictors of OSNew brain metastasesImproved overall survivalWhole brain radiationKaplan-Meier methodHigh-risk groupPredictors of outcomeProportional hazards methodsMulti-institutional settingMulti-institutional validationInitial salvageInitial SRSBrain metastasesBrain radiationSalvage modalityInitial treatmentRecurrence rateValidation cohortBrain failureBMV groupHazards methods
2018
SURG-15. UPFRONT MRI-GUIDED STEREOTACTIC LASER-ABLATION IN NEWLY DIAGNOSED GLIOBLASTOMA: A MULTICENTER REVIEW OF SURVIVAL OUTCOMES COMPARED TO A MATCHED COHORT OF BIOPSY-ONLY PATIENTS
Mohammadi A, Sharma M, Beaumont T, Juarez K, Kemeny H, Dechant C, Seas A, Sarmey N, Lee B, Jia X, Fecci P, Baehring J, Moliterno J, Chiang V, Ahluwalia M, Kim A, Barnett G, Leuthardt E. SURG-15. UPFRONT MRI-GUIDED STEREOTACTIC LASER-ABLATION IN NEWLY DIAGNOSED GLIOBLASTOMA: A MULTICENTER REVIEW OF SURVIVAL OUTCOMES COMPARED TO A MATCHED COHORT OF BIOPSY-ONLY PATIENTS. Neuro-Oncology 2018, 20: vi253-vi254. PMCID: PMC6216291, DOI: 10.1093/neuonc/noy148.1051.Peer-Reviewed Original ResearchSURG-06. LASER ABLATION FOR BRAIN METASTASES: SAFETY AND PRELIMINARY OUTCOMES FROM THE LASER ABLATION OF ABNORMAL NEUROLOGICAL TISSUE USING ROBOTIC NEUROBLATE SYSTEM (LAANTERN) REGISTRY
Kamath A, Tatter S, Fecci P, Chen C, Chiang V, Rao G, Mohammadi A, Judy K, Field M, Neimat J, Leuthardt E, Kim A. SURG-06. LASER ABLATION FOR BRAIN METASTASES: SAFETY AND PRELIMINARY OUTCOMES FROM THE LASER ABLATION OF ABNORMAL NEUROLOGICAL TISSUE USING ROBOTIC NEUROBLATE SYSTEM (LAANTERN) REGISTRY. Neuro-Oncology 2018, 20: vi251-vi251. PMCID: PMC6216263, DOI: 10.1093/neuonc/noy148.1042.Peer-Reviewed Original ResearchLaser interstitial thermal therapyBrain metastasesProcedural dataDeath rateAblation coverageMedian overall survivalAcceptable safety profileSingle-center experienceDay of procedureKaplan-Meier survivalNeurological tissuesAverage lesion volumeLocation of lesionsPreliminary outcomesInterstitial thermal therapyAdverse eventsOngoing registryOverall survivalCenter experienceSafety profileMean ageInvasive optionTarget lesionsProcedural efficacyLesion volumeSURG-20. LASER-INTERSTITIAL THERMAL THERAPY VERSUS CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY
Hong C, Deng J, Vera A, Chiang V. SURG-20. LASER-INTERSTITIAL THERMAL THERAPY VERSUS CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY. Neuro-Oncology 2018, 20: vi254-vi255. PMCID: PMC6216306, DOI: 10.1093/neuonc/noy148.1056.Peer-Reviewed Original ResearchLaser interstitial thermal therapyProgression-free survivalRe-growing tumorRadiation necrosisBrain metastasesMelanoma patientsSingle-surgeon retrospective studyImproved progression-free survivalLocal progression-free survivalPre-operative symptomsLog-rank testSteroid dosingSteroid taperNeurological outcomeOverall survivalRecurrent tumorsUnderwent craniotomyRetrospective studySingle institutionSubgroup analysisSurgery dateSurvival advantageCraniotomyPatientsLocal controlSalvage Stereotactic Radiosurgery is Associated with Improved Overall Survival Compared to Whole Brain Radiation in the Setting of Progressive Brain Metastases
Soike M, McTyre E, Farris M, Ayala-Peacock D, Hepel J, Page B, Kleinberg L, Contessa J, Chiang V, Cramer C, Ruiz J, Pasche B, Tatter S, Fiveash J, Ahluwalia M, Chao S, Braunstein S, Attia A, Chan M. Salvage Stereotactic Radiosurgery is Associated with Improved Overall Survival Compared to Whole Brain Radiation in the Setting of Progressive Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s144. DOI: 10.1016/j.ijrobp.2018.06.350.Peer-Reviewed Original ResearchDurability of brain metastasis response and overall survival in patients with non-small cell lung cancer (NSCLC) treated with pembrolizumab.
Goldberg S, Gettinger S, Mahajan A, Herbst R, Chiang A, Lilenbaum R, Jilaveanu L, Rowen E, Gerrish H, Komlo A, Wei W, Chiang V, Kluger H. Durability of brain metastasis response and overall survival in patients with non-small cell lung cancer (NSCLC) treated with pembrolizumab. Journal Of Clinical Oncology 2018, 36: 2009-2009. DOI: 10.1200/jco.2018.36.15_suppl.2009.Peer-Reviewed Original Research
2017
SURG-21. LASER ABLATION IN STEREOTACTIC NEUROSURGERY (LAISE): A MULTI-INSTITUTIONAL RETROSPECTIVE ANALYSIS OF LITT FOR NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMAS (GBMS)
Sloan A, Tatter S, Mohammadi A, Judy K, Prabhu S, Lovick D, Chamoun R, Chiang V, Leuthardt E. SURG-21. LASER ABLATION IN STEREOTACTIC NEUROSURGERY (LAISE): A MULTI-INSTITUTIONAL RETROSPECTIVE ANALYSIS OF LITT FOR NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMAS (GBMS). Neuro-Oncology 2017, 19: vi239-vi240. PMCID: PMC5693007, DOI: 10.1093/neuonc/nox168.977.Peer-Reviewed Original ResearchRecurrent GBMLaser interstitial thermotherapyRecurrent glioblastomaMulti-institutional retrospective analysisMedian ICU stayMedian overall survivalMedian patient ageTime of diagnosisLarger median volumeECOG statusICU stayConsecutive patientsOverall survivalPatient ageUnresectable tumorsRetrospective seriesMale genderTotal stayMedian volumeRetrospective analysisInvasive proceduresOutcome differencesBrain tumorsNewly DiagnosedPatients
2016
BMET-24. LASER ABLATION AFTER STEREOTACTIC RADIOSURGERY (LAASR) – RESULTS OF A MULTI-CENTERED PROSPECTIVE STUDY
Chiang V, Dietrich J, Tatter S, Mohammadi A, Leuthardt E, Chamoun R, Judy K, Barnett G, Ahluwalia M. BMET-24. LASER ABLATION AFTER STEREOTACTIC RADIOSURGERY (LAASR) – RESULTS OF A MULTI-CENTERED PROSPECTIVE STUDY. Neuro-Oncology 2016, 18: vi31-vi31. DOI: 10.1093/neuonc/now212.124.Peer-Reviewed Original ResearchKarnofsky performance statusProgression-free survivalProgressive brain metastasesOverall survivalRadiation necrosisBrain metastasesMedian Karnofsky performance statusMedian KPS scorePrimary tumor pathologyPrior stereotactic radiosurgeryStereotactic radiosurgery resultsQuality of lifeOutcomes of useRN patientsSteroid usageFree survivalHospital stayKPS scorePerformance statusRANO criteriaSecondary outcomesPrimary outcomeFACT-BrRecurrent tumorsTM patients