2024
Toxic and Metabolic Diseases of the CNS
Subramanian H, Mahajan A. Toxic and Metabolic Diseases of the CNS. What Radiology Residents Need To Know 2024, 231-244. DOI: 10.1007/978-3-031-55124-6_16.Peer-Reviewed Original ResearchCentral nervous systemMetabolic disordersBrain parenchymal involvementPredominant site of involvementSite of involvementNonspecific imaging appearancesDeep white matterParenchymal involvementDifferential diagnosisSpinal cordSevere casesImaging appearanceCerebral cortexCorpus callosumWhite matterMetabolic diseasesNervous systemPredominant siteToxic etiologyBasal gangliaSevere disordersDiagnosisDisordersImage patternsImage featuresPatterns of brain metastases response to immunotherapy with pembrolizumab
Mahajan A, Goldberg S, Weiss S, Tran T, Singh K, Joshi K, Aboian M, Kluger H, Chiang V. Patterns of brain metastases response to immunotherapy with pembrolizumab. Journal Of Neuro-Oncology 2024, 169: 555-561. PMID: 38963658, DOI: 10.1007/s11060-024-04754-8.Peer-Reviewed Original ResearchNon-small cell lung cancerBrain metastasesComplete resolutionLung cancerMedian time to CNS progressionLesion progressionNon-small cell lung cancer patientsModified RECIST criteriaPD-1 inhibitorsTrial of pembrolizumabEffective systemic treatmentResponse to immunotherapyPhase II trialCell lung cancerMethodsThis retrospective studyLocal treatment decisionsPurposeCentral nervous systemCNS progressionRECIST criteriaPD-1Local therapySystemic treatmentMRI evaluationResponse assessmentRetrospective studyImpact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers
Haider S, Zeevi T, Sharaf K, Gross M, Mahajan A, Kann B, Judson B, Prasad M, Burtness B, Aboian M, Canis M, Reichel C, Baumeister P, Payabvash S. Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266637. PMID: 38514087, DOI: 10.2967/jnumed.123.266637.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaSquamous cell carcinomaHuman papillomavirusRadiomic featuresIntraclass correlation coefficientCell carcinomaLentiform nucleusHuman papillomavirus statusReceiver-operating-characteristic analysisReceiver-operating-characteristic curvePET radiomic featuresUnivariate logistic regressionF-FDGPrimary tumorTraining cohortValidation cohortRadiomic biomarkersUnivariate analysisInterindividual comparabilityPredictive valueDegree of reproducibilityMedian areaRadiomic markersLogistic regressionAUC
2022
Development of a workflow efficient PACS based automated brain tumor segmentation and radiomic feature extraction for clinical implementation (N2.003)
Aboian M, Bousabarah K, Kazarian E, Zeevi T, Holler W, Merkaj S, Petersen G, Bahar R, Subramanian H, Sunku P, Schrickel E, Mahajan A, Malhotra A, Payabvash S, Tocino I, Lin M, Westerhoff M. Development of a workflow efficient PACS based automated brain tumor segmentation and radiomic feature extraction for clinical implementation (N2.003). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3146.Peer-Reviewed Original ResearchCerebral venous thrombosis after COVID-19 vaccination: the role for endovascular treatment
Mahajan A, Hirsch J. Cerebral venous thrombosis after COVID-19 vaccination: the role for endovascular treatment. Journal Of NeuroInterventional Surgery 2022, 14: 849-850. PMID: 35177518, DOI: 10.1136/neurintsurg-2021-018516.Peer-Reviewed Original Research
2021
The Utility of Imaging Parameters in Predicting Long-Term Clinical Improvement After Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus
Subramanian HE, Fadel SA, Matouk CC, Zohrabian VM, Mahajan A. The Utility of Imaging Parameters in Predicting Long-Term Clinical Improvement After Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus. World Neurosurgery 2021, 149: e1-e10. PMID: 33662608, DOI: 10.1016/j.wneu.2021.02.108.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusShunt surgeryNormal pressure hydrocephalusEvans indexCognitive improvementShunt placementPressure hydrocephalusImaging featuresLong-term patient-reported outcomesLong-term clinical improvementTelephone interviewsPreoperative imaging parametersVentriculoperitoneal shunt surgeryCerebrospinal fluid drainagePatient-reported outcomesLong-term outcomesLong-term cognitive improvementMagnetic resonance imagingImaging parametersClinical improvementGait improvementMedian durationClinical outcomesShunt candidatesFluid drainage
2020
The Spectrum of Neuroimaging findings on CT and MRI in Adults with Coronavirus Disease (COVID-19).
Moonis G, Filippi CG, Kirsch CFE, Mohan S, Stein EG, Hirsch JA, Mahajan A. The Spectrum of Neuroimaging findings on CT and MRI in Adults with Coronavirus Disease (COVID-19). AJR. American Journal Of Roentgenology 2020 PMID: 33236647, DOI: 10.2214/AJR.20.24839.Peer-Reviewed Original ResearchPrediction of post-radiotherapy locoregional progression in HPV-associated oropharyngeal squamous cell carcinoma using machine-learning analysis of baseline PET/CT radiomics
Haider SP, Sharaf K, Zeevi T, Baumeister P, Reichel C, Forghani R, Kann BH, Petukhova A, Judson BL, Prasad ML, Liu C, Burtness B, Mahajan A, Payabvash S. Prediction of post-radiotherapy locoregional progression in HPV-associated oropharyngeal squamous cell carcinoma using machine-learning analysis of baseline PET/CT radiomics. Translational Oncology 2020, 14: 100906. PMID: 33075658, PMCID: PMC7568193, DOI: 10.1016/j.tranon.2020.100906.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaLocoregional progressionSquamous cell carcinomaRisk stratificationCell carcinomaPrimary tumorBaseline PET/CT scansPET/CT scansBaseline PET/CTKaplan-Meier analysisPET/CT RadiomicsMetastatic cervical lymphPET/CTObjective imaging biomarkersLog-rank p-valueMedian C-indexCervical lymphCT radiomic featuresLocoregional failurePatient selectionTherapeutic challengeObjective biomarkersC-indexCT scanIndependent cohortMolecular Diagnosis and Extracranial Extension in Cushing Disease
Hong CS, Murari K, Gossmann M, Mahajan A, Erson-Omay Z, Manes RP, Omay SB. Molecular Diagnosis and Extracranial Extension in Cushing Disease. JAMA Otolaryngology - Head & Neck Surgery 2020, 146: 865-867. PMID: 32644156, DOI: 10.1001/jamaoto.2020.1471.Peer-Reviewed Original ResearchEvidence-Based Risk Mitigation and Stratification During COVID-19 for Return to Interventional Pain Practice: American Society of Interventional Pain Physicians (ASIPP) Guidelines.
Shah S, Diwan S, Soin A, Rajput K, Mahajan A, Manchikanti L, Kaye A, Hirsch J, Gharibo C. Evidence-Based Risk Mitigation and Stratification During COVID-19 for Return to Interventional Pain Practice: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician 2020, 23: s161-s182. PMID: 32942784, DOI: 10.36076/ppj.2020/23/s161.Peer-Reviewed Original ResearchConceptsAmerican Society of Interventional Pain PhysiciansContinuity of careChronic pain patientsPain specialistsInterventional pain physiciansPain patientsInterventional pain specialistsPain carePain physiciansRisk of COVID-19 morbidityEvidence-informed guidanceCOVID-19 pandemicRisk factorsCOVID-related morbidityEvaluate risk-benefitCare recommendationsNumerous risk factorsManaging symptomsEvidence synthesisDisclosure of conflictsInterventional Pain PracticePain practiceTelemedicine encountersRisk stratification toolGuideline preparationLack of Superiority of Epidural Injections with Lidocaine with Steroids Compared to Without Steroids in Spinal Pain: A Systematic Review and Meta-Analysis.
Knezevic N, Manchikanti L, Urits I, Orhurhu V, Vangala B, Vanaparthy R, Sanapati M, Shah S, Soin A, Mahajan A, Atluri S, Kaye A, Hirsch J. Lack of Superiority of Epidural Injections with Lidocaine with Steroids Compared to Without Steroids in Spinal Pain: A Systematic Review and Meta-Analysis. Pain Physician 2020, 23: s239-s270. PMID: 32942786, DOI: 10.36076/ppj.2020/23/s239.Peer-Reviewed Original ResearchConceptsRandomized controlled trialsSpinal painSystematic reviewInterventional Pain Management Techniques-Quality AppraisalMeta-analysisSecondary to disc herniationPost surgery syndromeEvidence synthesis principlesCochrane review criteriaEpidural injectionSystematic review of randomized controlled trialsReview of randomized controlled trialsMethodological quality assessmentLiterature searchPreferred Reporting ItemsPain reliefSecondary outcome measuresEffects of lidocaineIPM-QRBLocal anestheticsEvidence synthesisModerate evidenceMultiple randomized controlled trialsReporting ItemsDiscogenic painValue and Validity of Coronavirus Antibody Testing.
Mahajan A, Manchikanti L. Value and Validity of Coronavirus Antibody Testing. Pain Physician 2020, 23: s381-s390. PMID: 32942795, DOI: 10.36076/ppj.2020/23/s381.Peer-Reviewed Original ResearchConceptsAntibody testIgM antibodiesImmune response to SARS-CoV-2 infectionTesting health care workersInterventional proceduresElective interventional proceduresPain management communityResponse to SARS-CoV-2 infectionElective surgical proceduresDays post-symptom onsetSARS-CoV-2 infectionPost-symptom onsetInfected patientsSurgical proceduresViral infectionPatientsIgG antibodiesImmunoglobulin MRe-infectionDetect IgGInfectionSARS-CoV-2Total antibodiesAntibodiesIgG/IgM testChoice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging
Mur T, Sambhu KM, Mahajan A, Payabvash S, Fernandez J, Edwards HA. Choice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging. American Journal Of Otolaryngology 2020, 41: 102662. PMID: 32858370, DOI: 10.1016/j.amjoto.2020.102662.Peer-Reviewed Original ResearchConceptsPET/CTLow-dose nonenhanced CTDistant metastasisChest CTNeck cancerNonenhanced CTF-fluorodeoxyglucose positron emission tomographyF-FDG PET/CTDiagnostic chest CTDistant metastatic diseaseInitiation of therapyRetrospective cohort studyPre-treatment stagingTertiary care settingSignificant differencesPositron emission tomographyMetastatic diseaseCohort studyOncologic treatmentTNM stagingInaccurate stagingNeck radiologistsCare settingsSingle patientPatientsPotential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
Haider SP, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kann BH, Judson BL, Prasad ML, Burtness B, Mahajan A, Payabvash S. Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma. Cancers 2020, 12: 1778. PMID: 32635216, PMCID: PMC7407414, DOI: 10.3390/cancers12071778.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaProgression-free survivalPositron emission tomographySquamous cell carcinomaOverall survivalC-indexRisk stratificationCell carcinomaSurvival prognosticationHPV-negative oropharyngeal squamous cell carcinomaPre-treatment PET/CTMetastatic cervical lymph nodesBaseline positron emission tomographyBaseline distant metastasesCervical lymph nodesHuman papillomavirus (HPV) statusAmerican Joint CommitteeKaplan-Meier analysisPET/CT RadiomicsHarrell's C-indexAverage C-indexPET/CTRadiomics imaging featuresCurative intentDistant metastasisPET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma
Haider SP, Mahajan A, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kucukkaya AS, Kann BH, Judson BL, Prasad ML, Burtness B, Payabvash S. PET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 47: 2978-2991. PMID: 32399621, DOI: 10.1007/s00259-020-04839-2.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaMetastatic cervical lymph nodesCervical lymph nodesLymph nodesSquamous cell carcinomaPrimary tumorPET/CTHPV associationCell carcinomaRadiomics signatureVolume of interestHuman papilloma virus associationHuman papillomavirus associationMulti-national cohortNon-contrast CTHPV statusFDG-PETExternal cohortVirus associationFinal modelTumorsRadiomic featuresCTSignificant differencesLesion featuresPembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial
Goldberg SB, Schalper KA, Gettinger SN, Mahajan A, Herbst RS, Chiang AC, Lilenbaum R, Wilson FH, Omay SB, Yu JB, Jilaveanu L, Tran T, Pavlik K, Rowen E, Gerrish H, Komlo A, Gupta R, Wyatt H, Ribeiro M, Kluger Y, Zhou G, Wei W, Chiang VL, Kluger HM. Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial. The Lancet Oncology 2020, 21: 655-663. PMID: 32251621, PMCID: PMC7380514, DOI: 10.1016/s1470-2045(20)30111-x.Peer-Reviewed Original ResearchConceptsBrain metastasis responseYale Cancer CenterPD-L1 expressionPhase 2 trialUntreated brain metastasesBrain metastasesAdrenal insufficiencyAdverse eventsMetastasis responseCNS diseaseCancer CenterCohort 2Cohort 1Eastern Cooperative Oncology Group performance statusTreatment-related serious adverse eventsModified Response Evaluation CriteriaStage IV NSCLCTreatment-related deathsAcute kidney injuryPD-1 blockadeSerious adverse eventsSolid Tumors criteriaPhase 2 studyProportion of patientsResponse Evaluation CriteriaDiagnosis and Management of pituitary disease with focus on the role of Magnetic Resonance Imaging
Mahajan A, Bronen RA, Mian AY, Omay SB, Spencer DD, Inzucchi SE. Diagnosis and Management of pituitary disease with focus on the role of Magnetic Resonance Imaging. Endocrine 2020, 68: 489-501. PMID: 32162185, DOI: 10.1007/s12020-020-02242-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma.
Kann BH, Hicks DF, Payabvash S, Mahajan A, Du J, Gupta V, Park HS, Yu JB, Yarbrough WG, Burtness BA, Husain ZA, Aneja S. Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma. Journal Of Clinical Oncology 2019, 38: 1304-1311. PMID: 31815574, DOI: 10.1200/jco.19.02031.Peer-Reviewed Original ResearchConceptsNeck squamous cell carcinomaExtranodal extensionSquamous cell carcinomaLymph nodesCell carcinomaContrast-enhanced CT scanDiagnostic abilityBoard-certified neuroradiologistsTreatment escalationCancer Genome AtlasPathologic confirmationPretreatment identificationDiagnostic challengeExternal validation data setsPathology resultsPretreatment imagingPoor prognosticatorClinical utilityCT scanPatientsClinical decisionHNSCCDiagnostic accuracyInstitutional ValidationGenome AtlasFrequent Use of Local Therapy Underscores Need for Multidisciplinary Care in the Management of Patients With Melanoma Brain Metastases Treated With PD-1 Inhibitors
Qian JM, Yu JB, Mahajan A, Goldberg SB, Kluger HM, Chiang VLS. Frequent Use of Local Therapy Underscores Need for Multidisciplinary Care in the Management of Patients With Melanoma Brain Metastases Treated With PD-1 Inhibitors. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: 1113-1118. PMID: 31479702, DOI: 10.1016/j.ijrobp.2019.08.053.Peer-Reviewed Original ResearchConceptsBrain metastasesLocal therapyNeurologic safetyMelanoma patientsProspective phase 2 trialProgressive brain metastasesSerial brain imagingMelanoma brain metastasesPD-1 inhibitorsPhase 2 trialRapid disease progressionManagement of patientsNeurologic symptomsMultidisciplinary careTrial enrollmentCystic changesClinical trialsDisease progressionPatientsLesion sizeMetastasisMultidisciplinary teamTumor growthTherapyClinical decisionPerilesional edema in brain metastases: potential causes and implications for treatment with immune therapy
Tran TT, Mahajan A, Chiang VL, Goldberg SB, Nguyen DX, Jilaveanu LB, Kluger HM. Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy. Journal For ImmunoTherapy Of Cancer 2019, 7: 200. PMID: 31362777, PMCID: PMC6668163, DOI: 10.1186/s40425-019-0684-z.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAntibodies, Monoclonal, HumanizedAntigens, CD34Antineoplastic Agents, ImmunologicalBlood-Brain BarrierBrain EdemaBrain NeoplasmsCarcinoma, Non-Small-Cell LungClinical Trials, Phase II as TopicDrug Administration ScheduleHumansLung NeoplasmsMelanomaRetrospective StudiesTight JunctionsTreatment OutcomeTumor Cells, CulturedConceptsMelanoma brain metastasesBrain metastasesPerilesional edemaVessel densityEdema volumeSensitive tumorsBlood-brain barrier model systemNon-small cell lungTight junction resistancePhase II clinical trialSignificant perilesional edemaUntreated brain metastasesBlood-brain barrierPre-clinical modelsDegree of edemaTumor mass effectPotential causesMelanoma brainShort-term cultureExtracranial metastasesImmune therapyMelanoma patientsSignificant morbidityCell lungLarge tumors