2024
Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectin
2005
Dynamic Properties of Network Motifs Contribute to Biological Network Organization
Prill R, Iglesias P, Levchenko A. Dynamic Properties of Network Motifs Contribute to Biological Network Organization. PLOS Biology 2005, 3: e343. PMID: 16187794, PMCID: PMC1239925, DOI: 10.1371/journal.pbio.0030343.Peer-Reviewed Original ResearchConceptsBiological networksRobust dynamical stabilityLarge-scale dynamic systemsNon-random networksBiological network organizationDeep interplayDynamical stabilityDynamical propertiesDynamic systemsSmall perturbationsExhaustive computational analysisSystem dynamicsDynamical implicationsSmaller subnetworksNon-random structureNetwork motifsNetwork structureDynamic propertiesNetworkComputational analysisPropertiesPerturbationsRobustnessDynamicsStability
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply