Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectinSpatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12 DOI: 10.7554/elife.89262.3.Peer-Reviewed Original ResearchCell fate specificationStalk cellsCell type-specificTip cellsNotch signalingFate specificationStalk cell differentiationMorphogenic processesDensity of fibronectinType-specificCell typesCell-cell communicationComplex morphogenic processesResponse to elevated levelsCell fateCell identityDynamics of spatial patternsDepletion of fibronectinEnvironmental cuesSignaling moleculesBlood vessel sproutingSprout extensionAngiogenic morphogenesisSignaling pathwayHypoxic micro-environment
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