A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A. A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell 2020, 183: 94-109.e23. PMID: 32937105, DOI: 10.1016/j.cell.2020.08.031.Peer-Reviewed Original ResearchConceptsPhagocytic receptor MertkNetwork of macrophagesVentricular dysfunctionCardiac stressCardiac macrophagesDefective eliminationMetabolic alterationsOrgan functionImpaired autophagyHealthy myocardiumMyocardial tissueMurine heartMacrophagesMetabolic demandsCardiomyocytesMetabolic stabilityHeartAutophagy machineryMitochondrial homeostasisDysfunctional mitochondriaHomeostasisMembranous particlesDysfunctionInflammasomeMyocardium
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