2021
Guideline - Adherence in advanced stage head and neck cancer is associated with improved survival – A National study
Cohen O, Brauer PR, Judson BL, Burtness BA, Earles J, Mehra S. Guideline - Adherence in advanced stage head and neck cancer is associated with improved survival – A National study. Oral Oncology 2021, 125: 105694. PMID: 34971883, DOI: 10.1016/j.oraloncology.2021.105694.Peer-Reviewed Original ResearchConceptsOverall survivalNCCN guidelinesGuideline adherenceAdherence ratesNeck cancerAdvanced stage HNCGuideline adherence rateOverall stage IIINational Cancer DatabaseDecreased overall survivalAdvanced-stage headPrevalence of guidelinesComorbidity scoreAdherent patientsAdvanced headClinical stagingImproved survivalGuideline awarenessHNC patientsBlack raceInsurance statusNational cohortCancer DatabaseRisk factorsFemale genderBile reflux and hypopharyngeal cancer
Vageli DP, Doukas SG, Doukas PG, Judson BL. Bile reflux and hypopharyngeal cancer. Oncology Reports 2021, 46: 244. PMID: 34558652, PMCID: PMC8485019, DOI: 10.3892/or.2021.8195.Peer-Reviewed Original ResearchConceptsHypopharyngeal cancerAcidic bileHypopharyngeal carcinogenesisBile refluxRisk factorsGastroesophageal reflux diseaseIndependent risk factorSquamous cell cancerUpper aerodigestive tractElevated p53 expressionAnti-apoptotic effectsReflux diseaseLaryngopharyngeal refluxAerodigestive tractCell cancerGastroesophageal refluxateContribution of STAT3Neck cancerPrecancerous lesionsPremalignant changesNeoplastic changesNF-κBDNA damageP53 expressionBile acidsA 2020 Update on Public Awareness of Head and Neck Cancers
Torabi SJ, Kasle DA, Su-Velez B, Mehra S, Day TA, Yarbrough WG, St. John M, Judson BL. A 2020 Update on Public Awareness of Head and Neck Cancers. Otolaryngology 2021, 166: 305-312. PMID: 33845657, DOI: 10.1177/01945998211006932.Peer-Reviewed Original ResearchConceptsHuman papillomavirusHPV's roleNeck cancerNeck Cancer Awareness WeekKnowledge of HNCSigns/symptomsFormer tobacco usersCross-sectional surveyFormer smokersOropharyngeal cancerRisk factorsTobacco usersElderly individualsRisk populationsAwareness rateUS populationOlder individualsFuture outreach effortsCancerCausal roleHNCAwareness WeekUS CensusExposureHead
2020
The role of vitamin D in head and neck cancer
Izreig S, Hajek M, Edwards HA, Mehra S, Sasaki C, Judson BL, Rahmati RW. The role of vitamin D in head and neck cancer. Laryngoscope Investigative Otolaryngology 2020, 5: 1079-1088. PMID: 33364397, PMCID: PMC7752058, DOI: 10.1002/lio2.469.Peer-Reviewed Original ResearchVitamin DIntensive multi-modal therapyNeck squamous cell carcinomaManagement of HNSCCRise of immunotherapySet of malignanciesSquamous cell carcinomaMulti-modal therapyTreatment of HNSCCActive hormone calcitriolLimited data existsConsiderable morbiditySignificant morbiditySafe interventionCell carcinomaNeck cancerHormone calcitriolPatient outcomesEffective modalityHNSCCAdvanced stageMEDLINE databaseAvailable evidenceCalcium physiologyMorbidity
2018
HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes
Cheraghlou S, Torabi SJ, Husain ZA, Otremba MD, Osborn HA, Mehra S, Yarbrough WG, Burtness BA, Judson BL. HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes. The Laryngoscope 2018, 129: 684-691. PMID: 30151832, DOI: 10.1002/lary.27475.Peer-Reviewed Original ResearchConceptsHPV-negative patientsTreatment deintensificationCN3 diseaseHPV statusNeck cancerUnivariate Kaplan-Meier analysisTumor human papillomavirus (HPV) statusCox survival regressionHPV-negative diseaseIdentifiable primary tumorUnknown primary headHPV-positive patientsHuman papillomavirus (HPV) statusTumor HPV statusKaplan-Meier analysisTreatment-related outcomesSignificant prognostic valuePoor patient survivalCases of headDefinitive chemoradiotherapyDefinitive radiotherapyMetastatic nodesNodal classificationUnknown primaryTherapeutic challengePrognostic Value of Lymph Node Yield and Density in Head and Neck Malignancies
Cheraghlou S, Otremba M, Yu P, Agogo GO, Hersey D, Judson BL. Prognostic Value of Lymph Node Yield and Density in Head and Neck Malignancies. Otolaryngology 2018, 158: 1016-1023. PMID: 29460685, DOI: 10.1177/0194599818756830.Peer-Reviewed Original ResearchConceptsLymph node densityLymph node yieldNeck dissectionNode yieldNeck malignanciesLaird random-effects modelElective neck dissectionEnglish language original researchOvid/EmbaseOvid/MedlineHeterogeneity of studiesRandom-effects modelAdjuvant therapyNodal yieldNonduplicate articlesPrognostic significancePrognostic valuePatient counselingNeck cancerPooled resultsPatient outcomesPoor survivalPubMed databaseSurvival analysisDissection
2017
Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report
Barbiero FJ, Huttner AJ, Judson BL, Baehring JM. Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report. CNS Oncology 2017, 06: 281-285. PMID: 28990793, PMCID: PMC6004886, DOI: 10.2217/cns-2017-0004.Peer-Reviewed Original ResearchConceptsMandibular nerveRight mandibular nerveRight cavernous sinusSmooth muscle differentiationNerve biopsyCase reportMass lesionNeck cancerCavernous sinusMalignant tumorsGI tractInfratemporal fossaMedical literatureLeiomyosarcomaSkin appendagesSimilar casesNerveTumorsMuscle differentiationPeculiar patternDiplopiaHeadacheBiopsyPatientsMyometrium
2015
Investigation of the presence of HPV related oropharyngeal and oral tongue squamous cell carcinoma in Mozambique
Blumberg J, Monjane L, Prasad M, Carrilho C, Judson BL. Investigation of the presence of HPV related oropharyngeal and oral tongue squamous cell carcinoma in Mozambique. Cancer Epidemiology 2015, 39: 1000-1005. PMID: 26590333, PMCID: PMC6384508, DOI: 10.1016/j.canep.2015.10.015.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaOral tongue squamous cell carcinomaTongue squamous cell carcinomaHuman papillomavirusCell carcinomaCervical cancerOral tongueNeck cancerBiopsy samplesBiopsy proven squamous cell carcinomaEvidence of HPVRetrospective single-institution reviewOropharyngeal squamous cell carcinomaPresence of HPVRole of HPVAbsence of HPVHPV-positive cervical cancerHigh-risk human papillomavirusRisk human papillomavirusPositive cervical cancerSingle-institution reviewSingle referral hospitalHPV-16 E6Tongue casesOropharyngeal cancerRefusal of postoperative radiotherapy and its association with survival in head and neck cancer
Schwam ZG, Husain Z, Judson BL. Refusal of postoperative radiotherapy and its association with survival in head and neck cancer. Radiotherapy And Oncology 2015, 117: 343-350. PMID: 26508285, DOI: 10.1016/j.radonc.2015.10.013.Peer-Reviewed Original ResearchConceptsNeck cancer patientsPostoperative radiotherapyPredictive factorsCancer patientsOverall survivalNegative nodesThree-year overall survivalCox proportional hazards analysisNational Cancer DatabaseProportional hazards analysisLong-term outcomesMultivariable logistic regressionSlow disease progressionCharlson scorePathologic variablesImproved survivalKaplan-MeierNeck cancerCancer DatabaseDisease progressionRetrospective analysisMultivariate analysisPatientsLogistic regressionSelect headNational treatment patterns in patients presenting with Stage IVC head and neck cancer: analysis of the National Cancer Database
Schwam ZG, Burtness B, Yarbrough WG, Mehra S, Husain Z, Judson BL. National treatment patterns in patients presenting with Stage IVC head and neck cancer: analysis of the National Cancer Database. Cancer Medicine 2015, 4: 1828-1835. PMID: 26471244, PMCID: PMC5123708, DOI: 10.1002/cam4.546.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCombined Modality TherapyComorbidityDatabases, FactualFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingPopulation SurveillanceRetrospective StudiesRisk FactorsTreatment OutcomeUnited StatesYoung AdultConceptsNational Cancer DatabaseSystemic therapyPalliative therapyTreatment patternsNeck cancerCancer DatabaseClinical trialsMedicaid/uninsured statusCox proportional hazards analysisCommon treatment regimenNational treatment patternsCharlson comorbidity scorePrimary disease siteRetrospective cohort analysisProportional hazards analysisRisk of deathNeck cancer patientsMedicare/Comorbidity scoreMetastatic headOverall survivalSystemic treatmentTreatment regimenDistant metastasisKaplan-Meier
2014
Factors Associated with the Use of Intensity‐Modulated Radiotherapy for Head and Neck Cancer
Chen M, Roman S, Sosa J, Judson B. Factors Associated with the Use of Intensity‐Modulated Radiotherapy for Head and Neck Cancer. Otolaryngology 2014, 151: p164-p164. DOI: 10.1177/0194599814541629a85.Peer-Reviewed Original ResearchIntensity-modulated radiotherapyNeck cancer patientsConcurrent chemotherapyPostoperative radiotherapyCancer patientsPostoperative intensity-modulated radiotherapyNational Cancer DatabaseProportion of patientsHuman papillomavirus positivityHospital-level variationNeck cancer treatmentStudent's t-testClinical characteristicsNeck cancerCancer DatabasePractice patternsRetrospective analysisMAIN OUTCOMEWhite raceAcademic centersPrimary modalityMultivariate analysisPatientsRadiotherapyPrivate insuranceTrends and variations in the use of adjuvant therapy for patients with head and neck cancer
Chen MM, Roman SA, Yarbrough WG, Burtness BA, Sosa JA, Judson BL. Trends and variations in the use of adjuvant therapy for patients with head and neck cancer. Cancer 2014, 120: 3353-3360. PMID: 25042524, DOI: 10.1002/cncr.28870.Peer-Reviewed Original ResearchConceptsAdjuvant therapyAdverse pathologic featuresAdjuvant chemoradiationPathologic featuresNeck cancerNational Comprehensive Cancer Network guidelinesNational Cancer Data BaseMedicare/Medicaid insuranceImproved overall survivalHospital-level factorsCox multivariate regressionLog-rank testMultivariate logistic regressionForm of radiotherapyQuality of careAdjuvant radiotherapyOverall survivalMedicaid insuranceNetwork guidelinesCancer CenterLaryngeal cancerPractice patternsChemoradiationOral cavityPatientsPublic Awareness of Head and Neck Cancers: A Cross-Sectional Survey
Luryi AL, Yarbrough WG, Niccolai LM, Roser S, Reed SG, Nathan CA, Moore MG, Day T, Judson BL. Public Awareness of Head and Neck Cancers: A Cross-Sectional Survey. JAMA Otolaryngology - Head & Neck Surgery 2014, 140: 639-646. PMID: 24902640, DOI: 10.1001/jamaoto.2014.867.Peer-Reviewed Original ResearchConceptsRisk factorsThroat cancerHPV infectionNeck cancerDisease burdenTobacco useKnowledge of HNCHuman papillomavirus infectionLifestyle risk factorsKnowledge of signsCross-sectional surveyPapillomavirus infectionSore throatSubstantial morbidityMouth cancerCommon symptomsHuman papillomavirusMAIN OUTCOMEUS adultsBrain cancerSpecific questioningCancerSymptomsEarly detectionInfection