Characterization of a Smallâmolecule Modulator of IRE1α Activity
SalamiâOyenuga J, Raina K, Crews C. Characterization of a Smallâmolecule Modulator of IRE1α Activity. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.723.2.Peer-Reviewed Original ResearchUnfolded protein responseHuman IRE1αIRE1α activityInositol-Requiring Enzyme 1X-box binding protein 1 (XBP1) mRNAER stress conditionsEnzymatic activitySmall molecule modulatorsMechanism of regulationER stress responseHEK293T cellsThermal shift assayER stress pathwayEndoplasmic reticulum stressCellular processesER lumenUPR signalingShift assaysIRE1α activationProtein responseHuman kidney cellsIRE1α kinaseStress responseIRE1α proteinCentral player
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