A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
Ganga A, Sweeney L, Rubio Ramos A, Wrinn C, Bishop C, Hamel V, Guichard P, Breslow D. A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. Current Biology 2024, 34: 4824-4834.e6. PMID: 39317195, PMCID: PMC11496028, DOI: 10.1016/j.cub.2024.08.058.Peer-Reviewed Original ResearchCentrosome functionKinase-phosphatase pairSystems genetics approachDisorders of gonadal developmentCentriolar localizationCentriole proteinsGrowth defectSystems geneticsPhosphatase subunitFunctional partnersCentrosomal proteinsGene functionMicrotubule organizationCentrosome regulationGenetic approachesPPP2R3CJNK signalingCell signalingKinase activityCentrosome biogenesisAcute overexpressionGonadal developmentRegulatory mechanismsMAP3K1Gonadal dysgenesis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply