2011
ÎČ-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas
Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. ÎČ-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas. Cancer Cell 2011, 20: 741-754. PMID: 22172720, PMCID: PMC3241928, DOI: 10.1016/j.ccr.2011.10.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationBenzamidesbeta CateninCell Transformation, NeoplasticColorectal NeoplasmsEnzyme ActivationGene Knockdown TechniquesHumansImatinib MesylateKaplan-Meier EstimateLung NeoplasmsLymphatic MetastasisMelanocytesMelanoma, ExperimentalMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicPhosphorylationPiperazinesProtein StabilityProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePyrimidinesSignal TransductionSkin NeoplasmsSplenic NeoplasmsTranscription, GeneticTumor Cells, CulturedConceptsÎ-catenin levelsPI3K/AktLymph nodesMetastatic tumorsFrequent metastasisTumor differentiationMalignant melanomaMAPK/ERKMelanoma metastasesMouse modelControl metastasisHuman melanomaMelanomaMetastasisÎ-catenin stabilizationPTEN lossCentral mediatorMetastasis regulatorsÎ-cateninSpecific changesFunctional implicationsWntLung
2004
Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin
Provost E, McCabe A, Stern J, Lizardi I, D'Aquila TG, Rimm DL. Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin. Oncogene 2004, 24: 2667-2676. PMID: 15829978, DOI: 10.1038/sj.onc.1208346.Peer-Reviewed Original ResearchConceptsThreonine residuesÎ-cateninStable MDCK cell linesCell linesCadherin-mediated adhesionMutant ÎČ-cateninMutant cell linesExon 3Stable cell linesDestruction motifKinase substrateTranscriptional activationUbiquitination statusMultifunctional proteinMDCK cell lineCellular transformationTarget genesKey serineFunctional implicationsTransforming propertiesMutationsResiduesMotifG34Ubiquitination
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