2019
Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment
De Coen R, Nuhn L, Perera C, Arista-Romero M, Risseeuw M, Freyn A, Nachbagauer R, Albertazzi L, Van Calenbergh S, Spiegel D, Peterson B, De Geest B. Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment. Biomacromolecules 2019, 21: 793-802. PMID: 31829561, DOI: 10.1021/acs.biomac.9b01483.Peer-Reviewed Original ResearchConceptsImmune systemAntibody-mediated effector functionsTarget cell surfaceHuman serumEffector functionsCell surface membraneCell surface receptorsTarget cellsMonoclonal antibodiesAntibodiesAntibody recruitmentImmunotherapeuticsSmall molecule compoundsSerumCell surfaceLipophilic end groupsEnd groups
2010
A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules
Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmiercak B, Spiegel DA. A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules. ACS Chemical Biology 2010, 5: 1147-1155. PMID: 20923200, PMCID: PMC3003768, DOI: 10.1021/cb100195d.Peer-Reviewed Original ResearchConceptsCell wallCell wall engineeringCell-wall peptidoglycanWild-type bacteriaGram-positive bacterial pathogensPathogenic Gram-positive bacteriaStaphylococcus aureus cell wallBacterial cell wallBacterial cell surfaceEnzyme sortase ASmall moleculesGram-positive bacteriaWall peptidoglycanAureus cell wallMolecular handleBiosynthetic strategiesCell surfaceBacterial pathogensEndogenous levelsSortase AAzide-alkyne cycloaddition reactionChemical handlesWall engineeringBacteriaWidespread utility
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