2022
Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study
Wang Y, Zhao P, Chu C, Du MF, Zhang XY, Zou T, Hu GL, Zhou HW, Jia H, Liao YY, Chen C, Ma Q, Wang D, Yan Y, Sun Y, Wang KK, Niu ZJ, Zhang X, Man ZY, Wu YX, Wang L, Li HX, Zhang J, Li CH, Gao WH, Gao K, Lu WH, Desir GV, Delles C, Chen FY, Mu JJ. Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study. Hypertension 2022, 79: 1247-1256. PMID: 35360932, PMCID: PMC9093226, DOI: 10.1161/hypertensionaha.121.18658.Peer-Reviewed Original ResearchConceptsLong-term blood pressure variabilitySubclinical kidney damageAverage real variabilityBlood pressure variabilityLong-term visitCreatinine ratioUrinary albuminMean BPKidney damageCardiovascular diseasePressure variabilityHigh riskCumulative exposureHanzhong Adolescent Hypertension StudyVisit blood pressure variabilityProspective cohort studyGlomerular filtration rateRisk of albuminuriaClinical characteristicsCohort studyOngoing cohortKidney diseaseHypertension StudyFiltration rateAlbuminuria
2021
Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma
Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn S, Lacy J, Kunstman JW, H. C, Bellin MD, Robert ME, Desir GV, Gorelick FS. Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma. PLOS ONE 2021, 16: e0250539. PMID: 34587190, PMCID: PMC8480607, DOI: 10.1371/journal.pone.0250539.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Pancreatic DuctalCase-Control StudiesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMonoamine OxidaseNeoplasm GradingPancreatic NeoplasmsPrognosisProspective StudiesRetrospective StudiesSurvival AnalysisUp-RegulationYoung AdultConceptsPlasma renalase levelsBorderline resectable PDACRenalase levelsPDAC precursor lesionsOverall survivalPDAC tissuesTumor characteristicsResectable PDACChronic pancreatitisPrecursor lesionsNormal pancreasPancreatic ductal adenocarcinoma growthAdvanced tumor characteristicsVaried clinical stagesWorse tumor characteristicsNode-positive diseasePancreatic ductal adenocarcinomaNormal pancreatic headSpindle-shaped cellsPlasma renalaseRenalase expressionUnderwent resectionAbdominal traumaPancreatic headPositive disease
2010
A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study
Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study. PLOS ONE 2010, 5: e13496. PMID: 20975995, PMCID: PMC2958117, DOI: 10.1371/journal.pone.0013496.Peer-Reviewed Original ResearchConceptsPoor exercise capacityExercise capacityInducible ischemiaCardiac hypertrophyDiastolic dysfunctionSystolic dysfunctionStable coronary artery diseaseMissense polymorphismTreadmill exercise capacityCoronary artery diseaseSoul StudyVentricular dysfunctionArtery diseaseVentricular hypertrophyStress echocardiographyCommon missense polymorphismCC genotypeIschemiaTherapeutic implicationsCG genotypeCardiac structureDysfunctionHypertrophyRenalaseLogistic regression