2022
Cancer-Associated Hypercalcemia
Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. New England Journal Of Medicine 2022, 386: 1443-1451. PMID: 35417639, DOI: 10.1056/nejmcp2113128.Peer-Reviewed Original Research
2000
Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53
Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2000, 12: 71-81. PMID: 11132926, DOI: 10.3727/096504001108747549.Peer-Reviewed Original ResearchAllelesAnimalsBlotting, WesternCarcinoma, Squamous CellCodonGene Expression Regulation, NeoplasticGenes, p53HumansMiceMutagenesis, Site-DirectedMutationMutation, MissenseParathyroid Hormone-Related ProteinPlasmidsPoint MutationPrecipitin TestsPromoter Regions, GeneticProtein ConformationProtein DenaturationProtein IsoformsProteinsRNA, MessengerTransfectionTumor Cells, CulturedTumor Suppressor Protein p53
1996
Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.
Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM. Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53. Cancer Research 1996, 56: 4056-62. PMID: 8752179.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus E1B ProteinsCarcinoma, Squamous CellGene ExpressionGenes, p53Genes, ReporterHumansIsomerismKeratinocytesMutationParathyroid Hormone-Related ProteinPromoter Regions, GeneticProtein BiosynthesisProteinsRNA, MessengerTATA BoxTransfectionTumor Cells, CulturedTumor Suppressor Protein p53ConceptsHormone-related protein gene expressionPTHrP expression levelsSquamous carcinoma linesHormone-related proteinNormal secretory productP53 functional statusSquamous carcinoma cellsPTHrP gene expressionHuman squamous carcinoma cellsMutant p53 isoformsHumoral hypercalcemiaSquamous carcinomaFunctional statusPTHrP expressionPTHrP mRNASquamous epitheliumEndogenous mutant p53Mutant isoformsP53 isoformsCarcinoma linesWild-type p53Carcinoma cellsGene expressionCodon 248PTHrP transcriptsTransactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice.
Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Research 1996, 56: 1043-9. PMID: 8640759.Peer-Reviewed Original ResearchConceptsPTHrP gene expressionPTHrP mRNA expressionSquamous tumorsTumor linesAthymic miceMRNA expressionParathyroid hormone-related proteinOccurrence of hypercalcemiaPTHrP mRNA levelsHormone-related proteinSquamous histologyGene expressionPTHrP secretionHumoral hypercalcemiaSquamous carcinomaPTHrP gene promoterPTHrP mRNAHypercalcemiaSecretion ratePTHrP geneTumor cellsTumorsMRNA levelsHigh levelsHHM