2010
Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks
Yan KK, Fang G, Bhardwaj N, Alexander RP, Gerstein M. Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 9186-9191. PMID: 20439753, PMCID: PMC2889091, DOI: 10.1073/pnas.0914771107.Peer-Reviewed Original ResearchConceptsTranscriptional regulatory networksRegulatory networksCellular design principlesCall graphEvolutionary ratesGlobal regulatorOperating systemRandom mutationsSoftware systemsLiving organismBiological evolutionRapid evolutionSubsequent selectionFunctional modulesComputer operating systemsRegulatorNetwork hubsBiological systemsDesign principlesControl networkGeneric componentsHierarchical layoutGenomeEvolutionTerms of topology
2006
Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights
Kim PM, Lu LJ, Xia Y, Gerstein MB. Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights. Science 2006, 314: 1938-1941. PMID: 17185604, DOI: 10.1126/science.1136174.Peer-Reviewed Original Research