2021
Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions
Dehner CA, Ruff WE, Greiling T, Pereira MS, Redanz S, McNiff J, Girardi M, Kriegel MA. Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions. JID Innovations 2021, 2: 100084. PMID: 35199089, PMCID: PMC8844718, DOI: 10.1016/j.xjidi.2021.100084.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT cell activationSkin microbiotaAppropriate genetic backgroundCell activationBacillus speciesCutaneous T-cell lymphoma lesionsUnique microbiotaHuman commensalGenetic backgroundCell explantsClonal T-cell proliferationSkin-homing CD4T-cell lymphomaAdaptive immune responsesCell interactionsT cell proliferationT cell interactionsEnvironmental factorsMicrobial triggersMicrobiotaCommensalCTCL lesionsLymphoma lesionsCytokine secretionChapter 25 Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome
Greiling T, Vieira S, Kriegel M. Chapter 25 Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome. 2021, 211-221. DOI: 10.1016/b978-0-12-814551-7.00025-8.Peer-Reviewed Original ResearchSystemic lupus erythematosusSjögren's syndromeLupus erythematosusSystemic autoimmunityAdaptive immune responsesPathogenesis of autoimmunityToll-like receptorsProne hostsBarrier organsImmune responseAdaptive immunityInnate triggersAnimal modelsMicrobiota influenceCommensal bacteriaSyndromeMucus membranesAutoimmunityHuman autoantigensErythematosusPathogenesisMicrobiotaLive bacteriaHost tissuesInflammationChapter 9 Immunopathogenesis: the role of mucosal and skin microbiota in SLE
Greiling T, Kriegel M. Chapter 9 Immunopathogenesis: the role of mucosal and skin microbiota in SLE. 2021, 117-130. DOI: 10.1016/b978-0-12-820583-9.00012-9.Peer-Reviewed Original Research
2018
Skin Microbiota as Antigenic Triggers for Cutaneous T Cell Lymphoma
Dehner C, Ruff W, Foss F, Girardi M, Kriegel M. Skin Microbiota as Antigenic Triggers for Cutaneous T Cell Lymphoma. The Journal Of Immunology 2018, 200: 166.24-166.24. DOI: 10.4049/jimmunol.200.supp.166.24.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT-cell lymphomaT cellsSkin lesionsCell lymphomaPathogenesis of CTCLActive skin lesionsCutaneous T-cellChronic skin lesionsAdaptive immune responsesPatient T cellsSLE patientsCTCL patientsAntigenic triggerLesional skinRRNA sequencingAntigenic challengeMALT lymphomaHealthy donorsImmune responseAntigenic driversSkin commensalsPatient biopsiesClonal proliferationV1-3
2017
Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome
Dehner C, Ruff W, Vieira S, Goodman A, Kriegel M. Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.184.7.Peer-Reviewed Original ResearchBALB/c miceAdaptive immune systemAntiphospholipid syndromeB cellsC miceT cellsCell epitopesImmune systemPathogenic T cell epitopesTetramer-positive T cellsCD4 memory T cellsMemory T cellsTNF-α ILAdaptive immune responsesT cell clonesT cell epitopesDose-responsive mannerHuman commensal bacteriumB-cell epitopesEpitope-specific monoclonal antibodiesIL-21Patient PBMCsLymph nodesGPI antibodiesAntigenic challenge
2015
A common gut commensal as a cross-reactive candidate in antiphospholipid syndrome (HUM3P.250)
Dehner C, Ruff W, VIEIRA S, Goodman A, Kriegel M. A common gut commensal as a cross-reactive candidate in antiphospholipid syndrome (HUM3P.250). The Journal Of Immunology 2015, 194: 121.10-121.10. DOI: 10.4049/jimmunol.194.supp.121.10.Peer-Reviewed Original ResearchAntiphospholipid syndromeGut commensalsCD4 memory T cellsB-cell immunodominant epitopesWestern blottingIL-17 secretionMemory T cellsB cell responsesAdaptive immune responsesCommon gut commensalPatient plasma samplesAPS patientsIL-10IL-2IL-4T cellsImmune responseImmunodominant epitopesGut microbiotaTh1 clonesMajor autoantigenMolecular mimicryCell responsesPlasma samplesAntigenic potential