2016
The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity
Jeffery E, Wing A, Holtrup B, Sebo Z, Kaplan JL, Saavedra-Peña R, Church CD, Colman L, Berry R, Rodeheffer MS. The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity. Cell Metabolism 2016, 24: 142-150. PMID: 27320063, PMCID: PMC4945385, DOI: 10.1016/j.cmet.2016.05.012.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAdipose TissueAdipose Tissue, WhiteAnimalsDiet, High-FatFemaleHyperplasiaMaleMiceObesityOrgan SizeSex CharacteristicsConceptsVisceral white adipose tissueHigh-fat dietAdipose tissueAdipocyte precursorsAdipocyte hyperplasiaDepot-specific adipogenesisDifferential fat distributionObesity-associated pathologiesWhite adipose tissueAdipose tissue microenvironmentSubcutaneous adipose tissueAdipose tissue growthCell-intrinsic mechanismsMetabolic healthFat distributionMale miceHormone-dependent mannerDimorphic distributionObesityHyperplasiaAdipogenesisTissue microenvironmentTissueMicroenvironmentPlastic cells
2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery E, Church CD, Holtrup B, Colman L, Rodeheffer MS. Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity. Nature Cell Biology 2015, 17: 376-385. PMID: 25730471, PMCID: PMC4380653, DOI: 10.1038/ncb3122.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, WhiteAdipogenesisAdipose Tissue, WhiteAndrostadienesAnimalsCell ProliferationDiet, High-FatEatingMaleMiceMice, Inbred C57BLMice, KnockoutObesityPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-aktRandom AllocationTamoxifenWortmanninConceptsWhite adipose tissueAdipocyte precursorsMolecular mechanismsWAT growthNew adipocytesHigh-fat diet feedingCharacteristics of obesityOnset of obesityDistinct molecular mechanismsActivation of adipogenesisAdipocyte precursor cellsWAT massVisceral depotsDiet feedingMale miceAdipose tissueObesityAkt2 pathwayMature adipocytesPrecursor cellsAdipogenesisAdipocytesExcessive accumulationMiceActivation
2011
Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development 2011, 138: 4709-4719. PMID: 21989915, PMCID: PMC3190384, DOI: 10.1242/dev.067710.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAdipogenesisAdipose Tissue, WhiteAnimalsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene Regulatory NetworksHumansMaleMiceMice, Inbred C57BLMice, TransgenicMicroarray AnalysisNF-E2-Related Factor 2Promoter Regions, GeneticProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-ets-2ConceptsTranscription factorsWhite adipose tissue developmentGene networksAdipose tissue developmentGene expressionTissue developmentETS transcription factorsEarly gene clusterDistinct transcriptional programsWAT developmentAdipocyte differentiation programImportant transcription factorFormation of adipocytesMotif discovery toolsGene clusterEarly adipogenesisTranscriptional programsDifferentiation programBAC transgenic miceDNA microarraysDevelopmental transitionsMolecular mechanismsMolecular characterizationSignificant enrichmentEts2