A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression
Cai D, Huang M, Cao J, Hou J, Zhu L, Zhang L, Pero A, Guo L, Julia T, Zhong M, Goate A, Zhang B, Yan R. A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043247.Peer-Reviewed Original ResearchSynaptic functionAPOE genotypeEndo-lysosomal traffickingReticulon 3Strongest genetic risk factorWhole brain lysateNon-demented subjectsPostmortem brain samplesGenetic risk factorsAMP-AD consortiumDifferent brain regionsHuman postmortem brain samplesLOAD patientsRisk factorsAD pathogenesisMolecular signaling mechanismsSporadic ADDisease pathogenesisSynaptosomal fractionBrain samplesMouse brainApoE4Brain regionsCognitive functionSynaptojanin 1
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