2019
Adaptive Immunity: Antigen Recognition by T and B Lymphocytes
Kavathas P, Krause P, Ruddle N. Adaptive Immunity: Antigen Recognition by T and B Lymphocytes. 2019, 55-74. DOI: 10.1007/978-3-030-25553-4_4.ChaptersB cell receptorCell receptorMajor histocompatibility complexB lymphocytesKiller T cellsEffective immune responseVariety of antigensT cell receptors (TCRs) bindCentral toleranceT cellsImmune responseHLA proteinsAntigen recognitionHistocompatibility complexIntracellular pathogensCell surfaceReceptorsHLALymphocytesCorresponding antibodiesHost cellsAntibodiesIsotypesMHC systemDefense mechanisms
2016
Lymphotoxin
Ruddle N. Lymphotoxin. 2016, 466-475. DOI: 10.1016/b978-0-12-374279-7.10003-7.Peer-Reviewed Original ResearchTumor necrosis factorNFκB pathwayChronic inflammatory infiltrateAlternative NFκB pathwayMajor histocompatibility complexLymph nodesInflammatory infiltrateChemokine expressionChronic inflammationLymphoid organsNecrosis factorImmune responseCanonical NFκB pathwaySpecific antigenTNF receptorLymphotoxinLTβ receptorHistocompatibility complexTNF familyCulture supernatantsEmbryological developmentLymphocytesLTαCytotoxic activityReceptors
2013
Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles
Mionnet C, Mondor I, Jorquera A, Loosveld M, Maurizio J, Arcangeli ML, Ruddle NH, Nowak J, Aurrand-Lions M, Luche H, Bajénoff M. Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles. PLOS Biology 2013, 11: e1001672. PMID: 24130458, PMCID: PMC3794863, DOI: 10.1371/journal.pbio.1001672.Peer-Reviewed Original ResearchConceptsStromal cell typesB cell folliclesT cell zonesCell typesFate-mapping systemStromal cellsCellular demandB cellsLymph Node Stromal CellsSurvival signalsStromal cell subsetsB cell ablationLN stromal cellsCell zoneAdhesive substrataCell ablationCell subsetsImmune responseCellsFolliclesInflammationSubstrataRegulationTransient boundaryLymphocytes
2008
Antigen‐induced Lymph Node Remodeling: LVs, HEVs and Conduits
Stranford S, Liao S, Bentley K, Ruddle F, Ruddle N. Antigen‐induced Lymph Node Remodeling: LVs, HEVs and Conduits. The FASEB Journal 2008, 22: 392.3-392.3. DOI: 10.1096/fasebj.22.1_supplement.392.3.Peer-Reviewed Original ResearchHigh endothelial venulesLymph nodesAntigen encounterLymphatic vesselsLymph node remodelingLYVE-1T cell areasSecondary lymphoid organsAntigen-specific lymphocytesER-TR7Lymphoid organsAfferent lymphaticsEndothelial venulesMice transgenicTransgenic miceVascular interactionsDay 4Endothelial cellsAbluminal surfaceLymphocytesAntigenMarkersExpressionEGFP expressionVessels
1994
Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin
De Togni P, Goellner J, Ruddle N, Streeter P, Fick A, Mariathasan S, Smith S, Carlson R, Shornick L, Strauss-Schoenberger J, Russell J, Karr R, Chaplin D. Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin. Science 1994, 264: 703-707. PMID: 8171322, DOI: 10.1126/science.8171322.Peer-Reviewed Original ResearchConceptsPeripheral lymphoid organsPeripheral bloodLymphoid organsT cellsDetectable lymph nodesT cell subsetsLymph nodesCD4-CD8Cell subsetsPeyer's patchesMice DeficientImmunoglobulin MWhite pulpLymphotoxinLytic functionNormal ratioAbnormal developmentSpleenStem cellsBloodNormal developmentOrgansCellsLymphocytesThymus
1985
Lymphotoxin redux
Ruddle N. Lymphotoxin redux. Trends In Immunology 1985, 6: 156-159. PMID: 25289782, DOI: 10.1016/0167-5699(85)90144-6.Peer-Reviewed Original Research
1971
21 COULTER COUNTER EVALUATION OF THE DEATH OF FIBROBLASTS MEDIATED BY SENSITIZED LYMPHOCYTES IN THE PRESENCE OF SPECIFIC ANTIGEN
Ruddle N. 21 COULTER COUNTER EVALUATION OF THE DEATH OF FIBROBLASTS MEDIATED BY SENSITIZED LYMPHOCYTES IN THE PRESENCE OF SPECIFIC ANTIGEN. 1971, 401-407. DOI: 10.1016/b978-0-12-107750-1.50034-0.Peer-Reviewed Original Research
1968
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1237-1254. PMID: 4176937, PMCID: PMC2138572, DOI: 10.1084/jem.128.6.1237.Peer-Reviewed Original ResearchConceptsLymph node cellsTarget cell ratiosDelayed hypersensitivityNode cellsSoluble antigenSpecific antigenBovine gammaglobulinProgressive destructionCell ratioAntigen concentrationTarget cellsLymphocytesAntigenHypersensitivityCell enumerationEgg albuminCellsHrRat embryo fibroblastsTissue cultureLymphGammaglobulinRatsEmbryo fibroblastsCYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1267-1279. PMID: 5693925, PMCID: PMC2138574, DOI: 10.1084/jem.128.6.1267.Peer-Reviewed Original ResearchConceptsLymph node cellsNode cellsNormal lymph node cellsReaction of lymphocytesPresence of PPDDelayed hypersensitivitySoluble antigenSpecific antigenCytopathic effectAntigenPreincubation studiesTarget fibroblastsSensitized cellsMarked increaseAcid phosphatase contentLymphocytesSupernatant fluidCytotoxic activityPPDFibroblastsCellsPhosphatase contentHrRat embryo fibroblastsLymph