2024
Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis
Yang H, Li J, Huang X, Bucala R, Xu A, Lan H. Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis. Frontiers In Immunology 2024, 15: 1361343. PMID: 38846956, PMCID: PMC11153660, DOI: 10.3389/fimmu.2024.1361343.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorTreatment of immune-mediated kidney diseasesMacrophage MIFMIF depletionPathogenic roleSource of MIFImmune-mediated kidney diseasesAnti-glomerular basement membrane glomerulonephritisInhibitory factorT cell recruitmentGlomerular crescent formationTh17 immune responsesReduced serum creatininePolarization of macrophagesRenal macrophagesSerum creatinineCrescentic glomerulonephritisInhibiting Th1Renal injuryControl miceCreatine clearanceCrescent formationMembranous glomerulonephritisConditional ablation
1997
The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat
Lan H, Bacher M, Yang N, Mu W, Nikolic-Paterson D, Metz C, Meinhardt A, Bucala R, Atkins R. The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat. Journal Of Experimental Medicine 1997, 185: 1455-1466. PMID: 9126926, PMCID: PMC2196273, DOI: 10.1084/jem.185.8.1455.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibody FormationCell Adhesion MoleculesGene ExpressionGlomerulonephritisHypersensitivity, DelayedIntercellular Adhesion Molecule-1Interleukin-1Macrophage Migration-Inhibitory FactorsMaleMiceNitric Oxide SynthaseRabbitsRatsRats, Sprague-DawleyRNA, MessengerSkinTime FactorsVascular Cell Adhesion Molecule-1ConceptsMacrophage migration inhibitory factorControl antibody-treated animalsDelayed-type hypersensitivity responseAnti-MIF treatmentAntibody-treated animalsMigration inhibitory factorAdhesion molecule-1Hypersensitivity responseKidney diseaseLeukocytic infiltrationHistological damageCrescentic anti-glomerular basement membrane (GBM) glomerulonephritisMolecule-1Skin delayed-type hypersensitivity responseInducible nitric oxide synthase (iNOS) expressionAnti-glomerular basement membrane glomerulonephritisInhibitory factorVascular cell adhesion molecule-1Nitric oxide synthase expressionIntercellular adhesion molecule-1Cell adhesion molecule-1Rabbit anti-rat GBM serumProgressive renal injuryRenal function impairmentAnti-GBM glomerulonephritis