Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation
Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity 2023, 56: 2325-2341.e15. PMID: 37652021, PMCID: PMC10588993, DOI: 10.1016/j.immuni.2023.08.002.Peer-Reviewed Original ResearchChronic inflammationVascular macrophagesPersistent tissue injuryChronic inflammatory diseaseSmooth muscle cellsMacrophage nicheInflammation contributesChemokine CCL2Inflammatory diseasesPlaque areaTissue injuryVascular bedPlaque necrosisMacrophage phenotypeAdvanced stageHomeostatic functionsNecrotic coreMuscle cellsInflammationAtherosclerosisMacrophagesMural cellsIntravital imagingProtective nicheNecrotic cells
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