Loss of ZNF148 enhances insulin secretion in human pancreatic ÎČ cells
de Klerk E, Xiao Y, Emfinger C, Keller M, Berrios D, Loconte V, Ekman A, White K, Cardone R, Kibbey R, Attie A, Hebrok M. Loss of ZNF148 enhances insulin secretion in human pancreatic ÎČ cells. JCI Insight 2023, 8: e157572. PMID: 37288664, PMCID: PMC10393241, DOI: 10.1172/jci.insight.157572.Peer-Reviewed Original ResearchConceptsPancreatic ÎČ-cellsÎ-cellsSC-ÎČ cellsHuman pancreatic ÎČ-cellsInsulin secretionHuman ÎČ-cellsVesicle traffickingGenetic regulatorsStem cell-derived ÎČ cellsDirect repressionS100 genesCells identifiesZNF148Annexin A2Tetrameric complexCell membraneNovel therapeutic targetNovel therapeutic strategiesHuman isletsRegulatorTherapeutic targetCellsS100A16 expressionGlucose homeostasisTherapeutic strategies
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply