2000
The Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma
Ma D, Ariyan S. The Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 441-450. PMID: 10941564, DOI: 10.1016/s0094-1298(20)32739-5.Peer-Reviewed Original ResearchConceptsRecurrent malignant melanomaMalignant melanomaLimb perfusionTumor necrosis factor alphaRecurrent metastatic diseaseIsolated limb perfusionNecrosis factor alphaList of drugsHyperthermic ILPRecurrent diseaseMetastatic diseaseTumor loadLimb functionClinical trialsSurgical techniqueFactor alphaWound hygieneChemotherapeutic agentsMelanomaPerfusionDiseaseExtremitiesTreatmentHyperthermicTrials
1998
Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients
Ariyan S, Poo W. Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients. Surgery 1998, 123: 335-343. PMID: 9526527, DOI: 10.1016/s0039-6060(98)70188-6.Peer-Reviewed Original ResearchConceptsElderly patientsYounger patientsIsolated perfusionMeaningful disease controlRegional isolated perfusionEvidence of diseaseHigh-dose chemotherapySeries of patientsIsolated limb perfusionMajor surgical proceduresNumber of patientsDisease-free controlsYears of ageSalvage of limbsSignificant palliationThird perfusionAggressive treatmentDose chemotherapyOlder patientsRecurrent diseaseSurvival benefitTransit diseaseSerious complicationsRecurrent tumorsLimb perfusion
1996
Prolonged Survival in Patients with Advanced Melanoma Treated with Neoadjuvant Chemotherapy Followed by Resection
Sasson H, Poo W, Bakas M, Ariyan S. Prolonged Survival in Patients with Advanced Melanoma Treated with Neoadjuvant Chemotherapy Followed by Resection. Annals Of Plastic Surgery 1996, 37: 286-292. PMID: 8883727, DOI: 10.1097/00000637-199609000-00009.Peer-Reviewed Original ResearchConceptsStart of chemotherapySite of metastasisSurgical resectionPerformance statusResidual metastasesNeoadjuvant chemotherapyCombination chemotherapyMetastatic melanomaRetrospective analysisCompletion of chemotherapyCycles of chemotherapyConcomitant medical problemsDistant lymph nodesInitiation of therapySimilar clinical characteristicsTreatment of choiceNew combination regimensSignificant survival advantageDuration of survivalHigh response rateStable diseaseRecurrent diseaseClinical characteristicsMedian durationPartial response