2009
Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells
Anderson SM, Khalil A, Uduman M, Hershberg U, Louzoun Y, Haberman AM, Kleinstein SH, Shlomchik MJ. Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells. The Journal Of Immunology 2009, 183: 7314-7325. PMID: 19917681, PMCID: PMC4106706, DOI: 10.4049/jimmunol.0902452.Peer-Reviewed Original ResearchConceptsLow-affinity B cellsLow-affinity cellsGerminal centersB cellsHigh-affinity B cellsHigh-affinity cellsDeath rateHigh death rateLower death ratesImmune responseHigh-affinity AbsB lymphocytesMemory responsesExtracellular pathogensSame AgPrimary responseGC reactionProliferative advantageSimilar ratesSurvivalCellsCell cycleControl of survivalHigh affinityResponse
2003
Estimating Hypermutation Rates from Clonal Tree Data
Kleinstein SH, Louzoun Y, Shlomchik MJ. Estimating Hypermutation Rates from Clonal Tree Data. The Journal Of Immunology 2003, 171: 4639-4649. PMID: 14568938, DOI: 10.4049/jimmunol.171.9.4639.Peer-Reviewed Original Research