1981
High-volume intraperitoneal chemotherapy with methotrexate in patients with cancer.
Jones R, Collins J, Myers C, Brooks A, Hubbard S, Balow J, Brennan M, Dedrick R, DeVita V. High-volume intraperitoneal chemotherapy with methotrexate in patients with cancer. Cancer Research 1981, 41: 55-9. PMID: 7448776.Peer-Reviewed Original ResearchConceptsEpisodes of bacterial peritonitisNovel treatment modalitiesTotal body clearanceIntraperitoneal chemotherapyPeritoneal irritationChemotherapeutic regimensMethotrexate clearanceBacterial peritonitisOvarian cancerMalignant melanomaTreatment modalitiesLocal toxicitySystemic toxicityPlasma levelsPeritoneal cavitySystemic circulationTreatment cyclesPlasma concentrationsMethotrexate concentrationsTherapeutic benefitBody clearancePatientsMethotrexateChemotherapyPeritonitis
1978
Diffuse histiocytic lymphoma involving the gastrointestinal tract
Hande K, Fisher R, Devita V, Chabner B, Young R. Diffuse histiocytic lymphoma involving the gastrointestinal tract. Cancer 1978, 41: 1984-1989. PMID: 348299, DOI: 10.1002/1097-0142(197805)41:5<1984::aid-cncr2820410544>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsDiffuse histiocytic lymphomaBowel perforationComplete remissionSurgical resectionHistiocytic lymphomaGastrointestinal tractActive chemotherapeutic regimensMassive intestinal hemorrhageMajority of patientsResults of stagingRigorous stagingGastrointestinal lymphomaSystemic chemotherapySystemic therapyBowel lesionsChemotherapeutic regimensIntestinal hemorrhageDrug therapyRadiation therapyPatientsTumor resistanceLymphomaTherapyRelative rarityWidespread disease