2025
CAR-T Entering a New "Phase": Improving CAR-T Function by Harnessing Phase Separation.
Su X. CAR-T Entering a New "Phase": Improving CAR-T Function by Harnessing Phase Separation. Cancer Research 2025, 85: 1011-1012. PMID: 39879116, PMCID: PMC11910263, DOI: 10.1158/0008-5472.can-25-0357.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorFunction of CAR T cellsCAR-T cellsNext-generation cell therapyT cell receptor complexCAR-T functionMouse xenograft modelCytotoxicity in vitroCAR-TT cellsAntigen receptorAntitumor effectCell therapyXenograft modelCoreceptor signalingImmune responseImmunological synapseReceptor complexBiomolecular condensatesCytoplasmic tailCoreceptorTherapyCD3ELiquid-liquid phase separation
2019
A composition-dependent molecular clutch between T cell signaling condensates and actin
Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK. A composition-dependent molecular clutch between T cell signaling condensates and actin. ELife 2019, 8: e42695. PMID: 31268421, PMCID: PMC6624021, DOI: 10.7554/elife.42695.Peer-Reviewed Original Research
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