2023
H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome
Wang Z, Castillo-González C, Zhao C, Tong C, Li C, Zhong S, Liu Z, Xie K, Zhu J, Wu Z, Peng X, Jacob Y, Michaels S, Jacobsen S, Zhang X. H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome. Nature Communications 2023, 14: 7484. PMID: 37980416, PMCID: PMC10657422, DOI: 10.1038/s41467-023-43311-1.Peer-Reviewed Original ResearchConceptsDNA repair proteinsDNA repair pathwaysRepair pathwaysRepair proteinsWild-type plantsDefense-related genesArabidopsis resistanceHeterochromatin amplificationHeterochromatic regionsRAD51 recruitmentRep proteinGenomic instabilityHealthy plantsUnstable genomeHost genomeATXR6GeminivirusesRobust resistanceProteinViral amplificationGenomeMutantsViral DNATransposonPlants
2010
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases
Jacob Y, Stroud H, LeBlanc C, Feng S, Zhuo L, Caro E, Hassel C, Gutierrez C, Michaels SD, Jacobsen SE. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature 2010, 466: 987-991. PMID: 20631708, PMCID: PMC2964344, DOI: 10.1038/nature09290.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsArabidopsisArabidopsis ProteinsCatalytic DomainDNA MethylationDNA ReplicationDNA Transposable ElementsDNA, PlantGene Expression Regulation, PlantGene SilencingGenome, PlantHeterochromatinHistone-Lysine N-MethyltransferaseHistonesLysineMethylationMethyltransferasesMutant ProteinsMutationReplication Origin