2022
Zero-preserving imputation of single-cell RNA-seq data
Linderman GC, Zhao J, Roulis M, Bielecki P, Flavell RA, Nadler B, Kluger Y. Zero-preserving imputation of single-cell RNA-seq data. Nature Communications 2022, 13: 192. PMID: 35017482, PMCID: PMC8752663, DOI: 10.1038/s41467-021-27729-z.Peer-Reviewed Original ResearchConceptsSingle-cell RNA-sequencing dataSingle-cell RNA-seq dataNon-expressed genesRNA-sequencing dataRNA-seq dataExpression levelsBiological datasetsGenes
2021
Doubly Stochastic Normalization of the Gaussian Kernel Is Robust to Heteroskedastic Noise.
Landa B, Coifman RR, Kluger Y. Doubly Stochastic Normalization of the Gaussian Kernel Is Robust to Heteroskedastic Noise. SIAM Journal On Mathematics Of Data Science 2021, 3: 388-413. PMID: 34124607, PMCID: PMC8194191, DOI: 10.1137/20m1342124.Peer-Reviewed Original ResearchStochastic normalizationHeteroskedastic noiseGaussian kernelHigh-dimensional settingsMatrix convergesAmbient dimensionDifferent noise variancesEuclidean spaceData pointsNoise varianceSymmetric normalizationCertain normalizationAffinity matrixClean counterpartsPairwise distancesKernelNoiseData analysis techniqueSingle-cell RNA-sequencing dataParticular directionSpaceWidespread approachConvergesMatrixHeteroskedasticity