Yale Cancer Center

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A Genetic Screen Identifies a New Master Regulator of Brain Metastasis
A new study from scientists at Yale School of Medicine has identified N-acetyltransferase 10 (NAT10), an enzyme highly expressed in brain metastasis, as a driver of brain metastasis. NAT10 primarily functions by adding acetyl groups to RNA molecules, regulating their function, stability or translation.
26 Mar 2025
News
Driver of cystic fibrosis lung inflammation yields target for treatment
Yale researchers have uncovered a driver of the chronic inflammation that damages lungs in cystic fibrosis. It could be a target for treatment.
Source: Yale News
12 Dec 2022
News
New Yale Study Shows Potential Target for Treating Blood Cancers
Researchers in the Halene lab at the Yale Cancer Center have published a new study that unveils the potential mechanism behind the progression of certain types of blood cancers.
Source: Yale Daily News
31 Mar 2022
News
Yale Scientists Discover a New Pathogenic Mechanism in Hematological Malignancies
Scientists at Yale Cancer Center have discovered new consequences of specific gene mutations that play a role in the development of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Approximately half the patients diagnosed with MDS and 10% of patients with AML are found to have splicing factor mutations leading to ineffective blood cell production and malignancy. The new research revealed that mutations in the splicing factor U2AF1 improve the ability of the cancer cells to respond to and survive stress. The findings were published today in Molecular Cell.
17 Mar 2022
News
With Barcoding, a Better Understanding of Life Forms
Because of the very complicated organization of tissues and cells, it’s still not entirely understood how tumors form, for instance, or how different organs emerge in early-stage embryos. To help answer these crucial questions, a team of researchers at Yale have developed a technology that gives a much clearer picture of the spatial relationships in biological systems. The process, which involves barcoding cells in tissue, was developed in the lab of Rong Fan, professor of biomedical engineering. The results were published Nov. 13 in Cell. The authors include Yale BME postdocs, graduate students, and undergraduate students in Fan lab and collaborators from Yale School of Medicine including Prof. Stephanie Halene, interim section chief of hematology.
Source: Yale SEAS News
15 Nov 2020