Yale Cancer Center

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News
Six Yale Researchers Receive NIH ‘High-Risk, High-Reward’ Awards
Two Yale Cancer Center members are among six Yale researchers to receive High-Risk, High-Reward NIH grants.
Source: Yale News
9 Oct 2024
News
CAR T-Cell Therapy: Pathology Is Key to This Revolutionary Cancer Treatment
In a recent review article, a YSM pathologist described existing technologies for monitoring CAR T-cell therapy and important avenues for future research.
7 Oct 2024
News
Grants Awarded at YCC • 2024
Institutional support, federal funding, philanthropy and grants are the support that make cancer research possible.
28 Feb 2024
News
Xiaolei Su Wins Pershing Square Sohn Prize for Cancer Research
Dr. Xiaolei Su Receives prestigious Pershing Square Sohn Prize for Cancer Research
18 May 2023
News
Yale Scientist Receives Pershing Square Sohn Prize for Young Investigators in Cancer Research
Xiaolei Su, PhD, Assistant Professor of Cell Biology and a member of the Cancer Immunology (CI) Research Program at Yale Cancer Center has been awarded a Pershing Square Sohn Prize for Young Investigators in Cancer Research.
Source: Pershing Square Sohn Cancer Research Alliance
17 May 2023
News
Meet Our Speakers: Dr. Gillian Griffiths
Dr. Gillian Griffiths visited the department a few weeks ago. She sat down with Meg Tian to talk about her lab, her research and her advice for trainees.
7 May 2023
News
Su Receives Award from Gabrielle's Angel Foundation
Xiaolei Su, PhD, Assistant Professor of cell biology, received an award from the Gabrielle's Angel Foundation for Cancer Research.
17 Aug 2022
News
Phospholipase PLCγ1 promotes phase separation in T cells
Phospholipase Cγ1 (PLCγ1) hydrolyzes PIP2 to generate IP3 and DAG to transduce T cell receptor (TCR) signaling. We revealed a lipase-independent function of PLCγ1 in promoting phase separation of T cell signaling components. We showed that PLCγ1crosslinks LAT, a key adaptor protein in forming signaling condensates in the TCR pathway. PLCγ1 also protects LAT from CD45-mediated dephosphorylation and promotes downstream ERK activation and actin polymerization. Interestingly, PLCγ1 promotes LAT condensation only at low concentrations but not high concentrations. This could be explained by a change in internal organization of the condensates using a coarse-grained model-based simulation.
Source: Journal of Cell Biology
30 Apr 2021