2016
Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma
Chae WJ, Bothwell AL. Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma. Journal Of Thoracic Disease 2016, 8: e1010-e1012. PMID: 27747048, PMCID: PMC5059289, DOI: 10.21037/jtd.2016.08.19.Peer-Reviewed Original ResearchThymic stromal lymphopoietinHouse dust miteAllergic asthmaDendritic cellsType 2 inflammatory diseasesT helper type 2 cellsNaïve CD4 T cellsCD4 T cellsHumoral immune responseTh2 effector cellsT cell plasticityType 2 cellsLung epithelial cellsIL-25Lung eosinophiliaIL-33Effector cellsEnvironmental allergensTh2 cytokinesDust miteInflammatory diseasesT cellsImmune responseB cellsEpithelial cells
2015
Spontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL‐17A
Chae WJ, Bothwell AL. Spontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL‐17A. Journal Of Immunology Research 2015, 2015: 860106. PMID: 26146642, PMCID: PMC4469837, DOI: 10.1155/2015/860106.Peer-Reviewed Original ResearchConceptsApc miceGATA-3 expressionIntestinal tumorigenesisFamilial adenomatous polyposisT cell developmentAdoptive transferIL-17AT cellsFunctional regulatory T cellsNaïve CD4 T cellsFrequency of Foxp3Regulatory T cellsAbility of TregsGene mutationsCD4 T cellsSpontaneous intestinal tumorigenesisWild-type TregsHuman familial adenomatous polyposisApc mouse modelAPC gene mutationsCell developmentAltered T cell developmentInflammatory diseasesTregsLamina propria