2023
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention
Qiu B, Lawan A, Xirouchaki C, Yi J, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett A. MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention. Nature Communications 2023, 14: 5405. PMID: 37669951, PMCID: PMC10480499, DOI: 10.1038/s41467-023-41145-5.Peer-Reviewed Original Research
2011
Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27*
Flach RJ, Qin H, Zhang L, Bennett AM. Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27*. Journal Of Biological Chemistry 2011, 286: 22195-22202. PMID: 21521693, PMCID: PMC3121364, DOI: 10.1074/jbc.m110.210237.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase phosphatase-1Hepatic lipid homeostasisFatty acid oxidationLipid homeostasisMKP-1-deficient miceProtein kinase phosphatase-1MAPK-dependent phosphorylationFat-specific protein 27Like effector CPeroxisome proliferator-activated receptor-γ target genesProtein 27Kinase phosphatase-1Lipid droplet formationPhosphatase 1Acid oxidationLipogenic gene expressionSerine 112Target genesHepatic lipogenic gene expressionGene expressionPPARγ functionMetabolic signalsInhibitory residuesFactor AHepatic fatty acid oxidation
2007
Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses
Chi H, Bennett A, Flavell R. Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses. Journal Of Organ Dysfunction 2007, 3: 72-81. DOI: 10.1080/17471060601137415.Peer-Reviewed Original ResearchProtein kinase phosphatase-1Kinase phosphatase-1Innate immune responseMKP-1Toll-like receptorsPhosphatase 1Dual-specificity phosphataseImmune responseC-Jun N-terminal kinaseMKP-1 deficiencyN-terminal kinaseIntracellular negative regulatorTranscriptional inductionExcessive innate immune responseNegative regulatorBiochemical activityCritical regulatorMicrobial pathogensPhysiological functionsPro-inflammatory cytokinesP38 MAPKInnate immunityAutoimmune arthritisDendritic cellsInflammatory mediators