2021
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas
Norton J, Augert A, Eastwood E, Basom R, Rudin C, MacPherson D. Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas. Genes & Development 2021, 35: 870-887. PMID: 34016692, PMCID: PMC8168556, DOI: 10.1101/gad.348316.121.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsCarcinoma, Small CellCell DeathCell Line, TumorCOP9 Signalosome ComplexCyclopentanesDisease Models, AnimalGene Expression Regulation, NeoplasticHeterograftsHumansLung NeoplasmsMiceNEDD8 ProteinNeuroendocrine CellsProteinsPyrimidinesRepressor ProteinsSequence DeletionConceptsSmall cell lung carcinomaSmall cell carcinomaExtrapulmonary small cell carcinomaNeddylation inhibitionCell carcinomaCell statesGenome-scale CRISPR/Therapeutic targetPatient-derived xenograft modelsCell linesDeletion of componentsSolid tumor malignanciesCell lung carcinomaNovel therapeutic approachesPotential therapeutic targetSuppressor screenSCLC cell linesCOP9 signalosomeProtein neddylationCRISPR/Genetic suppressionPathway genesPDX modelsMajor regulatorLung carcinoma
2020
MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell 2020, 38: 97-114.e7. PMID: 32470392, DOI: 10.1016/j.ccell.2020.04.016.Peer-Reviewed Original Research
2019
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
Augert A, Eastwood E, Ibrahim A, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton K, Martins R, Poirier J, Rudin C, Milletti F, Cheng W, Mack F, MacPherson D. Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Science Signaling 2019, 12 PMID: 30723171, PMCID: PMC6530478, DOI: 10.1126/scisignal.aau2922.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsCell Line, TumorEnzyme InhibitorsGene Expression Regulation, NeoplasticHistone DemethylasesHumansKaplan-Meier EstimateLung NeoplasmsMice, Inbred NODMice, KnockoutMice, SCIDReceptors, NotchSignal TransductionSmall Cell Lung CarcinomaTumor BurdenXenograft Model Antitumor AssaysConceptsSmall cell lung cancerCell lung cancerNonsmall cell lung cancerLung cancerNotch activationLSD1 inhibitionPatient-derived xenograft modelsLSD1 inhibitorsReactivation of NotchFirst-line standardExpression of Ascl1Durable tumor regressionTranscription factor Ascl1Notch pathway activationLineage genesKnockdown studiesNotch pathwayDownstream signalingCare treatmentPDX modelsTumor regressionTargeted therapySCLC tumorigenesisActionable mutationsXenograft model
2018
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov 2018, 8: 1422-1437. PMID: 30181244, DOI: 10.1158/2159-8290.CD-18-0385.Peer-Reviewed Original Research
2017
Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).
Augert A, Zhang Q, Bates B, Cui M, Wang X, Wildey G, Dowlati A, MacPherson D. Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance). J Thorac Oncol 2017, 12: 704-713. PMID: 28007623, DOI: 10.1016/j.jtho.2016.12.011.Peer-Reviewed Original Research
2016
The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action.
Griveau A, Devailly G, Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker JM, Vindrieux D, Bernard D. The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action. Oncogene 2016, 35: 5033-42. PMID: 27041564, DOI: 10.1038/onc.2016.43.Peer-Reviewed Original ResearchMultidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape.
Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, Ferrand M, Augert A, Bernard D. Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene 2016, 35: 1596-601. PMID: 26073088, DOI: 10.1038/onc.2015.218.Peer-Reviewed Original Research
2014
Treating transcriptional addiction in small cell lung cancer.
Augert A, MacPherson D. Treating transcriptional addiction in small cell lung cancer. Cancer Cell 2014, 26: 783-784. PMID: 25490443, DOI: 10.1016/j.ccell.2014.11.012.Peer-Reviewed Original ResearchEndoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence.
Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun 2014, 5: 3792. PMID: 24797322, DOI: 10.1038/ncomms4792.Peer-Reviewed Original ResearchPTEN is a potent suppressor of small cell lung cancer.
Cui M, Augert A, Rongione M, Conkrite K, Parazzoli S, Nikitin AY, Ingolia N, MacPherson D. PTEN is a potent suppressor of small cell lung cancer. Mol Cancer Res 2014, 12: 654-9. PMID: 24482365, DOI: 10.1158/1541-7786.MCR-13-0554.Peer-Reviewed Original Research[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy].
Girard CA, Seitz-Polski B, Dolla G, Augert A, Vindrieux D, Bernard D, Lambeau G. [New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy]. Med Sci (Paris) 2014, 30: 519-25. PMID: 24939538, DOI: 10.1051/medsci/20143005014.Peer-Reviewed Original Research In PressRepression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth.
Vindrieux D, Devailly G, Augert A, Le Calvé B, Ferrand M, Pigny P, Payen L, Lambeau G, Perrais M, Aubert S, Simonnet H, Dante R, Bernard D. Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth. Oncotarget 2014, 5: 1004-13. PMID: 24657971, DOI: 10.18632/oncotarget.1681.Peer-Reviewed Original Research
2013
PLA2R1 kills cancer cells by inducing mitochondrial stress.
Augert A, Vindrieux D, Girard CA, Le Calvé B, Gras B, Ferrand M, Bouchet BP, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D. PLA2R1 kills cancer cells by inducing mitochondrial stress. Free Radic Biol Med 2013, 65: 969-977. PMID: 23994771, DOI: 10.1016/j.freeradbiomed.2013.08.177.Peer-Reviewed Original ResearchPLA2R1 mediates tumor suppression by activating JAK2.
Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res 2013, 73: 6334-45. PMID: 24008317, DOI: 10.1158/0008-5472.CAN-13-0318.Peer-Reviewed Original ResearchLysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Wiel C, Augert A, Vincent DF, Gitenay D, Vindrieux D, Le Calvé B, Arfi V, Lallet-Daher H, Reynaud C, Treilleux I, Bartholin L, Lelievre E, Bernard D. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis 2013, 4: e855. PMID: 24113189, DOI: 10.1038/cddis.2013.382.Peer-Reviewed Original ResearchPotassium channel KCNA1 modulates oncogene-induced senescence and transformation.
Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res 2013, 73: 5253-65. PMID: 23774215, DOI: 10.1158/0008-5472.CAN-12-3690.Peer-Reviewed Original ResearchPlatelet-derived growth factor B induces senescence and transformation in normal human fibroblasts.
Vindrieux D, Gras B, Garcia-Belinchon M, Mourah S, Lebbe C, Augert A, Bernard D. Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts. Aging (Albany NY) 2013, 5: 531-8. PMID: 23934686, DOI: 10.18632/aging.100577.Peer-Reviewed Original Research
2010
NUAK1 links genomic instability and senescence.
Bernard D, Augert A. NUAK1 links genomic instability and senescence. Aging (Albany NY) 2010, 2: 317-9. PMID: 20603521, DOI: 10.18632/aging.100153.Peer-Reviewed Original Research
2009
[Senescent-associated factors: pro- and anti-tumoral actions].
Augert A, Bernard D. [Senescent-associated factors: pro- and anti-tumoral actions]. Med Sci (Paris) 2009, 25: 789-90. PMID: 19849975, DOI: 10.1051/medsci/20092510789.Peer-Reviewed Original ResearchA genetic screen identifies topoisomerase 1 as a regulator of senescence.
Humbert N, Martien S, Augert A, Da Costa M, Mauen S, Abbadie C, de Launoit Y, Gil J, Bernard D. A genetic screen identifies topoisomerase 1 as a regulator of senescence. Cancer Res 2009, 69: 4101-6. PMID: 19435923, DOI: 10.1158/0008-5472.CAN-08-2864.Peer-Reviewed Original Research