2020
The role of vitamin D in head and neck cancer
Izreig S, Hajek M, Edwards HA, Mehra S, Sasaki C, Judson BL, Rahmati RW. The role of vitamin D in head and neck cancer. Laryngoscope Investigative Otolaryngology 2020, 5: 1079-1088. PMID: 33364397, PMCID: PMC7752058, DOI: 10.1002/lio2.469.Peer-Reviewed Original ResearchVitamin DIntensive multi-modal therapyNeck squamous cell carcinomaManagement of HNSCCRise of immunotherapySet of malignanciesSquamous cell carcinomaMulti-modal therapyTreatment of HNSCCActive hormone calcitriolLimited data existsConsiderable morbiditySignificant morbiditySafe interventionCell carcinomaNeck cancerHormone calcitriolPatient outcomesEffective modalityHNSCCAdvanced stageMEDLINE databaseAvailable evidenceCalcium physiologyMorbidity
2019
Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy
LOGANADANE G, KANN BH, PARK HS, JOHNSON SB, MEHRA S, JUDSON BL, BHATIA A, BELKACEMI Y, YARBROUGH WG, BURTNESS B, HUSAIN ZA. Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy. Anticancer Research 2019, 39: 4885-4890. PMID: 31519591, DOI: 10.21873/anticanres.13674.Peer-Reviewed Original ResearchConceptsLocoregional recurrence-free survivalAdjuvant therapyNeck squamous cell carcinomaOutcomes of patientsRecurrence-free survivalSquamous cell carcinomaNeck cancer patientsHNSCC patientsClinical outcomesRecurrence rateCell carcinomaMean TTPCancer patientsPatientsTherapyResectionMonthsOutcomesHNSCCSurgeryCarcinomaHeadIncidenceProgressionPrognostic Case Volume Thresholds in Patients With Head and Neck Squamous Cell Carcinoma
Torabi SJ, Benchetrit L, Yu P, Cheraghlou S, Savoca EL, Tate JP, Judson BL. Prognostic Case Volume Thresholds in Patients With Head and Neck Squamous Cell Carcinoma. JAMA Otolaryngology - Head & Neck Surgery 2019, 145: 708-715. PMID: 31194229, PMCID: PMC6567848, DOI: 10.1001/jamaoto.2019.1187.Peer-Reviewed Original ResearchLow-volume facilitiesHigh-volume facilitiesNeck squamous cell carcinomaFacility case volumeSquamous cell carcinomaCase volumeCell carcinomaHNSCC casesStage cancerUS National Cancer DatabaseMultivariable Cox regressionNational Cancer DatabaseImportant prognostic indicatorAdvanced-stage cancerCause mortality outcomesTreatment of HNSCCModerate-volume groupEligible patientsPrognostic meaningAdult patientsAnatomic subsiteCox regressionMean ageMortality outcomesPrognostic indicatorGender disparities in head and neck cancer chemotherapy clinical trials participation and treatment
Benchetrit L, Torabi SJ, Tate JP, Mehra S, Osborn HA, Young MR, Burtness B, Judson BL. Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment. Oral Oncology 2019, 94: 32-40. PMID: 31178210, DOI: 10.1016/j.oraloncology.2019.05.009.Peer-Reviewed Original ResearchConceptsChemotherapy clinical trialsNational Cancer DatabaseClinical trialsDefinitive radiotherapyChemotherapy administrationNational Comprehensive Cancer Network guidelinesMultivariable logistic regression analysisNeck squamous cell carcinomaEnd Results ProgramSquamous cell carcinomaClinical trial participationLogistic regression analysisGeneral U.S. populationChemotherapy useDefinitive chemoradiotherapyNCCN guidelinesAdult patientsDefinitive treatmentMultivariable analysisNetwork guidelinesResults ProgramCell carcinomaTrial participationCancer DatabaseU.S. patientsRadiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma
Lee NCJ, Kelly JR, An Y, Park HS, Judson BL, Burtness BA, Husain ZA. Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma. Cancer 2019, 125: 2018-2026. PMID: 30748002, PMCID: PMC6541535, DOI: 10.1002/cncr.32001.Peer-Reviewed Original ResearchConceptsHigh-volume surgical facilitiesPostoperative radiation therapyNeck squamous cell carcinomaSquamous cell carcinomaOverall survivalSurvival benefitCell carcinomaSurgical facilitiesPropensity score-matched cohortAnnual case volumeDefinitive surgeryAdvanced headOS improvementImproved outcomesRadiation therapyCase volumeOral cavityPatientsReduced hazardMultivariate analysisSurgeryInvasive HNSCCCarcinomaSurvivalTreatment
2018
Association of Human Papillomavirus Status at Head and Neck Carcinoma Subsites With Overall Survival
Li H, Torabi SJ, Yarbrough WG, Mehra S, Osborn HA, Judson B. Association of Human Papillomavirus Status at Head and Neck Carcinoma Subsites With Overall Survival. JAMA Otolaryngology - Head & Neck Surgery 2018, 144: 519-525. PMID: 29801040, PMCID: PMC6583856, DOI: 10.1001/jamaoto.2018.0395.Peer-Reviewed Original ResearchConceptsHPV-positive statusHuman papillomavirus (HPV) statusOverall survivalHPV statusOral cavityHPV positivityRetrospective population-based cohort studyPopulation-based cohort studyCox multivariate regression modelNeck squamous cell carcinomaHPV-negative statusImproved overall survivalNational Cancer DatabaseHPV-negative tumorsHPV-positive tumorsIndependent prognostic factorHuman papillomavirus positivityUpper aerodigestive tractSquamous cell carcinomaLarge survival differencesCategory tumorsOropharynx subsiteCohort studyPrimary malignancyImproved survival
2017
Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer
Biktasova A, Hajek M, Sewell A, Gary C, Bellinger G, Deshpande HA, Bhatia A, Burtness B, Judson B, Mehra S, Yarbrough WG, Issaeva N. Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer. Clinical Cancer Research 2017, 23: 7276-7287. PMID: 28916527, DOI: 10.1158/1078-0432.ccr-17-1438.Peer-Reviewed Original ResearchConceptsClinical trialsHNSCC cellsMatrix metalloproteinasesHuman papillomavirus-associated headNeck squamous cell carcinomaSquamous cell carcinomaAbility of HPVClin Cancer ResTumor cell proliferationNeck cancer cellsWindow trialsCell carcinomaEffective therapyPreclinical modelsHPVHPV oncogenesMouse modelMouse blood vesselsDNA demethylating agentHNSCCXenografted tumorsHPV genesIFN responseTherapyTumor samplesThe cancer-testis antigen, sperm protein 17, a new biomarker and immunological target in head and neck squamous cell carcinoma
Schutt CA, Mirandola L, Figueroa JA, Nguyen DD, Cordero J, Bumm K, Judson BL, Chiriva-Internati M. The cancer-testis antigen, sperm protein 17, a new biomarker and immunological target in head and neck squamous cell carcinoma. Oncotarget 2017, 5: 100280-100287. PMID: 29245977, PMCID: PMC5725019, DOI: 10.18632/oncotarget.22213.Peer-Reviewed Original ResearchNeck squamous cell carcinomaAutologous dendritic cellsAutologous tumor cellsSquamous cell carcinomaHNSCC patientsCancer-testis antigensDendritic cellsCell carcinomaNon-small cell lung cancerTumor cellsSp17 expressionIdeal immunotherapeutic targetSpecific cytotoxic lymphocytesCell lung cancerCurrent treatment modalitiesPotential serological biomarkerSperm protein 17Possible future targetsTherapeutic vaccinesImmunotherapeutic targetPoor prognosisAggressive malignancyMultiple myelomaPeripheral bloodTNM stage
2012
Prognostic significance of the AJCC staging in patients with squamous cell carcinoma of the oropharynx.
Acevedo-Gadea C, Baumgart M, Wang Z, Deshpande H, Davies M, Decker R, Sasaki C, Judson B, Herbst R, Morgensztern D. Prognostic significance of the AJCC staging in patients with squamous cell carcinoma of the oropharynx. Journal Of Clinical Oncology 2012, 30: 5529-5529. DOI: 10.1200/jco.2012.30.15_suppl.5529.Peer-Reviewed Original ResearchSquamous cell carcinomaOP cancerOverall survivalHuman papillomavirusOral cavityAJCC stagePrognostic significanceCell carcinomaStage IFrequency of HPVNeck squamous cell carcinomaCurrent AJCC systemEnd Results registryKaplan-Meier methodEpidemiology of headL. PatientsPrognostic impactAJCC stagingOropharyngeal cancerPrognostic factorsStage IVBSurveillance EpidemiologyAJCC systemPatient populationClinical behaviorInfluence of extracapsular extension on lymph node staging for patients with squamous cell carcinoma of the head and neck.
Baumgart M, Acevedo-Gadea C, Wang Z, Buta E, Davies M, Deshpande H, Decker R, Sasaki C, Judson B, Herbst R, Morgensztern D. Influence of extracapsular extension on lymph node staging for patients with squamous cell carcinoma of the head and neck. Journal Of Clinical Oncology 2012, 30: 5532-5532. DOI: 10.1200/jco.2012.30.15_suppl.5532.Peer-Reviewed Original ResearchPoor prognostic factorSquamous cell carcinomaExtracapsular extensionOral cavityOverall survivalPrognostic factorsCell carcinomaIndependent poor prognostic factorNeck squamous cell carcinomaCox proportional hazards modelSignificant OS differenceSquamous cell cancerProportional hazards modelPrognostic impactSurveillance EpidemiologyCell cancerPoor outcomeKaplan-MeierECE statusOS differenceAJCC manualEligibility criteriaHazards modelPrimary siteSurvival curves