2023
Extra imaging beyond NCCN surveillance guidelines is cost effective for HPV− but not HPV+ oropharyngeal cancer
Shah R, Tyagi S, Liu C, Judson B. Extra imaging beyond NCCN surveillance guidelines is cost effective for HPV− but not HPV+ oropharyngeal cancer. Oral Oncology 2023, 146: 106564. PMID: 37672950, DOI: 10.1016/j.oraloncology.2023.106564.Peer-Reviewed Original Research
2020
PET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma
Haider SP, Mahajan A, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kucukkaya AS, Kann BH, Judson BL, Prasad ML, Burtness B, Payabvash S. PET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 47: 2978-2991. PMID: 32399621, DOI: 10.1007/s00259-020-04839-2.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaMetastatic cervical lymph nodesCervical lymph nodesLymph nodesSquamous cell carcinomaPrimary tumorPET/CTHPV associationCell carcinomaRadiomics signatureVolume of interestHuman papilloma virus associationHuman papillomavirus associationMulti-national cohortNon-contrast CTHPV statusFDG-PETExternal cohortVirus associationFinal modelTumorsRadiomic featuresCTSignificant differencesLesion features
2017
Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base
Cheraghlou S, Yu PK, Otremba MD, Park HS, Bhatia A, Zogg CK, Mehra S, Yarbrough WG, Judson BL. Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base. Cancer 2017, 124: 717-726. PMID: 29243245, DOI: 10.1002/cncr.31104.Peer-Reviewed Original ResearchConceptsNational Cancer Data BaseStage III diseaseTriple-modality therapyAdjuvant radiotherapyOropharyngeal cancerStage IHuman papillomavirus-positive oropharyngeal cancerUnivariate Kaplan-Meier analysisAvoidance of chemotherapyDeintensification of treatmentEdition stage IStage II diseaseMultivariate Cox regressionAmerican Joint CommitteeKaplan-Meier analysisDisease stage groupsForm of treatmentTreatment deintensificationAdjuvant chemoradiotherapyDefinitive radiotherapyTreatment intensificationFavorable prognosisImproved survivalCox regressionRetrospective studyDemethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer
Biktasova A, Hajek M, Sewell A, Gary C, Bellinger G, Deshpande HA, Bhatia A, Burtness B, Judson B, Mehra S, Yarbrough WG, Issaeva N. Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer. Clinical Cancer Research 2017, 23: 7276-7287. PMID: 28916527, DOI: 10.1158/1078-0432.ccr-17-1438.Peer-Reviewed Original ResearchConceptsClinical trialsHNSCC cellsMatrix metalloproteinasesHuman papillomavirus-associated headNeck squamous cell carcinomaSquamous cell carcinomaAbility of HPVClin Cancer ResTumor cell proliferationNeck cancer cellsWindow trialsCell carcinomaEffective therapyPreclinical modelsHPVHPV oncogenesMouse modelMouse blood vesselsDNA demethylating agentHNSCCXenografted tumorsHPV genesIFN responseTherapyTumor samples
2016
Radiotherapy for human papillomavirus‐positive oropharyngeal cancers in the National Cancer Data Base
Cheraghlou S, Kuo P, Judson BL. Radiotherapy for human papillomavirus‐positive oropharyngeal cancers in the National Cancer Data Base. Cancer 2016, 122: 3410-3410. PMID: 27420896, DOI: 10.1002/cncr.30195.Peer-Reviewed Original Research
2015
Investigation of the presence of HPV related oropharyngeal and oral tongue squamous cell carcinoma in Mozambique
Blumberg J, Monjane L, Prasad M, Carrilho C, Judson BL. Investigation of the presence of HPV related oropharyngeal and oral tongue squamous cell carcinoma in Mozambique. Cancer Epidemiology 2015, 39: 1000-1005. PMID: 26590333, PMCID: PMC6384508, DOI: 10.1016/j.canep.2015.10.015.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaOral tongue squamous cell carcinomaTongue squamous cell carcinomaHuman papillomavirusCell carcinomaCervical cancerOral tongueNeck cancerBiopsy samplesBiopsy proven squamous cell carcinomaEvidence of HPVRetrospective single-institution reviewOropharyngeal squamous cell carcinomaPresence of HPVRole of HPVAbsence of HPVHPV-positive cervical cancerHigh-risk human papillomavirusRisk human papillomavirusPositive cervical cancerSingle-institution reviewSingle referral hospitalHPV-16 E6Tongue casesOropharyngeal cancerSevere epistaxis due to aberrant vasculature in a patient with STAT‐1 mutation
Chang MT, Schwam ZG, Hajek MA, Paskhover B, Judson BL. Severe epistaxis due to aberrant vasculature in a patient with STAT‐1 mutation. Head & Neck 2015, 38: e68-e70. PMID: 26445901, DOI: 10.1002/hed.24165.Peer-Reviewed Original Research