2024
Ten Year Follow-up After Face Transplantation – a Single Center Retrospective Cohort Study
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. Ten Year Follow-up After Face Transplantation – a Single Center Retrospective Cohort Study. American Journal Of Transplantation 2024 PMID: 39413877, DOI: 10.1016/j.ajt.2024.10.007.Peer-Reviewed Original ResearchChronic rejectionFace transplantationFollow-upSingle center retrospective cohort studyFunctional outcomesSensory returnAnalysis of functional outcomesMedian follow-upIncidence of malignancyMetabolic side effectsGraft rejection episodesComputed tomography angiogramRetrospective cohort studyEvidence of vasculopathyFollow-up periodLong-term outcomesYear follow-upFacial motor functionRejection episodesInfectious complicationsTransplant recipientsPatient ageGraft retentionMedical complicationsCohort studyEvolution of Vascularized Composite Allotransplantation
Huelsboemer L, Pomahac B. Evolution of Vascularized Composite Allotransplantation. 2024, 15-27. DOI: 10.1007/978-3-031-57132-9_3.Peer-Reviewed Original ResearchVascularized composite allotransplantationSolid organ transplantationProlongation of ischemia timeReconstruction of complex tissue defectsContext of vascularized composite allotransplantationDevelopment of non-toxicTolerogenic strategiesChronic rejectionImmunosuppressive medicationsTolerance inductionComplex tissue defectsPatient selectionIschemia timeImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection
2023
Insights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2020
Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation
Kaufman C, Kanitakis J, Weissenbacher A, Brandacher G, Mehra M, Amer H, Zelger B, Zelger B, Pomahac B, McDiarmid S, Cendales L, Morelon E. Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation. SAGE Open Medicine 2020, 8: 2050312120940421. PMID: 32704373, PMCID: PMC7361482, DOI: 10.1177/2050312120940421.Peer-Reviewed Original ResearchChronic rejectionComposite allograftsFunctional declineReconstructive transplantationComposite allotransplantationHistologic evidenceDe novo donor-specific antibodiesAmerican SocietyNovo donor-specific antibodiesNormal allograft functionDonor-specific antibodiesInternational SocietyVascularized Composite AllotransplantationAcute rejectionAllograft functionAllograft recipientsImmunosuppressive therapyTreatment regimensRisk factorsUterine transplantationUpper extremityMeeting reportAllograftsTransplantationClinical cases
2019
Novel immunological and clinical insights in vascularized composite allotransplantation
Kollar B, Pomahac B, Riella L. Novel immunological and clinical insights in vascularized composite allotransplantation. Current Opinion In Organ Transplantation 2019, 24: 42-48. PMID: 30531538, DOI: 10.1097/mot.0000000000000592.Peer-Reviewed Original ResearchConceptsAcute rejectionT cellsComposite allotransplantationField of VCANovel immunosuppressive approachAntibody-mediated rejectionCurrent histological classificationNovel noninvasive biomarkersQuality of lifeType of rejectionIntensity of treatmentFace transplant recipientsChronic rejectionImmunosuppressive regimensVCA patientsVCA recipientsAllograft injuryCostimulation blockadeImmunosuppressive approachesImmunosuppressive therapyTransplant recipientsImmune monitoringUpper extremityHistological classificationVCA outcomes
2018
Chronic rejection of human face allografts
Krezdorn N, Lian C, Wells M, Wo L, Tasigiorgos S, Xu S, Borges T, Frierson R, Stanek E, Riella L, Pomahac B, Murphy G. Chronic rejection of human face allografts. American Journal Of Transplantation 2018, 19: 1168-1177. PMID: 30312535, PMCID: PMC6433509, DOI: 10.1111/ajt.15143.Peer-Reviewed Original ResearchConceptsChronic rejectionComposite allograftsAutoimmune cutaneous disordersImmune-mediated changesLymphocyte-mediated cytotoxicityC-fosSevere facial disfigurementType IAcute rejectionSurveillance biopsiesIatrogenic immunosuppressionVascular ectasiaFollicular pluggingSystemic sclerosisHistopathologic evidenceClinical manifestationsPreventative therapyCutaneous disordersGraft durabilityFace allograftNasal mucosaPathologic changesPathologic alterationsEpidermal thinningSclerotic zone
2016
Treatment of Rejection in Vascularized Composite Allotransplantation
Alhefzi M, Aycart M, Bueno E, Kiwanuka H, Krezdorn N, Pomahac B, Tullius S. Treatment of Rejection in Vascularized Composite Allotransplantation. Current Transplantation Reports 2016, 3: 404-409. DOI: 10.1007/s40472-016-0128-3.Peer-Reviewed Original ResearchVascularized Composite AllotransplantationAcute rejectionChronic rejectionComposite allotransplantationTreatment of rejectionConventional reconstructive techniquesCommon complicationReconstructive techniquesEsthetic outcomeTherapeutic strategiesImportant modalityAllotransplantationRecent reportsTreatmentRejectionAllograftsComplicationsPreventionFacial Transplantation
Aycart M, Alhefzi M, Kueckelhaus M, Fischer S, Dermietzel A, Wo L, Bueno E, Pribaz J, Pomahac B. Facial Transplantation. 2016, 5: 93-102. DOI: 10.1159/000444969.Peer-Reviewed Original ResearchAcute rejectionFacial transplantationDevastating facial injuriesPulse-dose corticosteroidsSolid organ transplantationThorough preoperative planningDonor pool expansionShort-term resultsPowerful clinical toolChronic rejectionDose corticosteroidsHost diseaseImmunomodulatory approachesGraft preservationCertain patientsFunctional outcomeOrgan transplantationFacial injuriesMultidisciplinary teamSensory functionClinical toolPatient safetyPreoperative planningPsychosocial outcomesTransplantation
2015
Facial transplantation
Wo L, Bueno E, Pomahac B. Facial transplantation. Current Opinion In Organ Transplantation 2015, Publish Ahead of Print: &na;. PMID: 26536422, DOI: 10.1097/mot.0000000000000253.Peer-Reviewed Original ResearchConceptsPositive HIV statusHIV statusFace transplantComposite allotransplantationUpper extremity transplantsDonor-specific antigensHistory of malignancyLatent viral infectionFacial transplantationChronic rejectionSimultaneous transplantationAbsolute contraindicationCase reportCurrent guidelinesFacial injuriesViral infectionTransplantTransplantationMedical teamAllotransplantationFirst face transplantFace transplantationFacial allotransplantationPatientsPsychological healthNoninvasive Monitoring of Immune Rejection in Face Transplant Recipients
Kueckelhaus M, Imanzadeh A, Fischer S, Kumamaru K, Alhefzi M, Bueno E, Wake N, Gerhard-Herman M, Rybicki F, Pomahac B. Noninvasive Monitoring of Immune Rejection in Face Transplant Recipients. Plastic & Reconstructive Surgery 2015, 136: 1082-1089. PMID: 26505709, DOI: 10.1097/prs.0000000000001703.Peer-Reviewed Original ResearchConceptsFace transplant recipientsTransplant recipientsChronic rejectionCLINICAL QUESTION/LEVELAllograft biopsy specimensTotal vessel diameterSolid organ allograftsAllograft lossOrgan allograftsPostsurgical monitoringFlap arteryControl subjectsBiopsy specimensIntimal thicknessClinical signsRadial arteryThicker intimaUltrasound biomicroscopyFacial arteryMedia thicknessHistologic analysisImmune rejectionArteryRecipientsInterobserver correlationVascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration
Kueckelhaus M, Fischer S, Seyda M, Bueno E, Aycart M, Alhefzi M, ElKhal A, Pomahac B, Tullius S. Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration. Transplant International 2015, 29: 655-662. PMID: 26265179, PMCID: PMC4785085, DOI: 10.1111/tri.12652.Peer-Reviewed Original ResearchConceptsAcute rejectionImproved long-term graft outcomesLong-term graft outcomeChronic allograft deteriorationCytomegalovirus infection statusGraft preservation techniquesUpper extremity transplantationUpper extremity transplantsAntibody-mediated rejectionGood midterm resultsSpecific treatment strategiesAllograft deteriorationChronic rejectionClinical VCAVCA graftsGraft outcomeImmunosuppressive strategiesLocal immunosuppressionMidterm resultsExtremity transplantationCell-based therapiesHLA matchingTolerance inductionTreatment strategiesUS Centers
2013
Split rejection in vascularized composite allotransplantation.
Sinha I, Pomahac B. Split rejection in vascularized composite allotransplantation. Eplasty 2013, 13: e53. PMID: 24244785, PMCID: PMC3795428.Peer-Reviewed Original Research