2022
Longitudinal Recovery of Speech Motor Function Following Facial Transplantation: A Prospective Observational Study
Perry B, Eshghi M, Stipancic K, Richburg B, Ventresca H, Pomahac B, Green J. Longitudinal Recovery of Speech Motor Function Following Facial Transplantation: A Prospective Observational Study. The Laryngoscope 2022, 132: 2359-2367. PMID: 35218215, PMCID: PMC9402794, DOI: 10.1002/lary.30068.Peer-Reviewed Original ResearchConceptsFunctional speechSpeech intelligibilitySpeech recoveryLip strengthSpeech motor functionSpeech outcomesSentence intelligibility testMotor speech functionKinematic measuresProspective observational studyFacial transplantationRange of movementIntelligibility testIntelligibility improvementJaw rangeLongitudinal recoveryMotor functionObservational studyClinical measuresEarly recoveryJaw functionExtent of recoverySpeech functionSpeech improvementPatients
2021
Neuromotor Speech Recovery Across Different Behavioral Speech Modifications in Individuals Following Facial Transplantation
Eshghi M, Perry B, Richburg B, Ventresca H, Pomahac B, Green J. Neuromotor Speech Recovery Across Different Behavioral Speech Modifications in Individuals Following Facial Transplantation. Frontiers In Neurology 2021, 11: 593153. PMID: 33488496, PMCID: PMC7815523, DOI: 10.3389/fneur.2020.593153.Peer-Reviewed Original ResearchSpeech modificationsSpeech clarityArticulatory demandsLoud speechMotor systemSpeech-language pathologistsArticulatory stabilityArticulatory mechanismsSpeech intelligibilityEvidence-based practice approachCompensatory strategiesDysarthric speechSlow speechFacial transplantationSpeech recoverySpeech deficitsLanguage pathologistsNeuromotor recoveryNormal rangeExtent individualsStages of recoverySpeechFacial animationFace transplantationSpeech function
2019
The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation
Haug V, Kollar B, Obed D, Kiwanuka H, Turk M, Wo L, Tasigiorgos S, Kueckelhaus M, Riella L, Pomahac B. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 278-285. PMID: 30998810, PMCID: PMC6646986, DOI: 10.1001/jamafacial.2019.0076.Peer-Reviewed Original ResearchConceptsAcute rejectionSubtherapeutic tacrolimus levelsClinical signsRejection episodesImmunosuppressive therapySubclinical rejectionTacrolimus levelsMedical recordsOdds ratioFacial transplantationDiagnostic valueSignificant associationSingle-center cohort studyLate rejection episodesProtocol skin biopsiesSecond posttransplant yearSymptoms of rejectionTacrolimus blood levelsSecond postoperative yearReliable clinical signFull facial transplantationPostoperative yearPosttransplant yearYears posttransplantationAllograft rejection
2018
Software‐based video analysis of functional outcomes of face transplantation
Fischer S, Diehm Y, Dorante M, Kotsougiani D, Kueckelhaus M, Alhefzi M, Bueno E, Pomahac B. Software‐based video analysis of functional outcomes of face transplantation. Microsurgery 2018, 39: 53-61. PMID: 30159931, DOI: 10.1002/micr.30360.Peer-Reviewed Original ResearchConceptsFace transplantationNormal populationAssessment of outcomesDifferent time pointsFunctional outcomeFacial movementsPatient's abilitySame patientTransplantationMouth openingOutcome assessmentPatientsValuable assessment toolOpen mouthEye closureTime pointsRetrospective assessmentMonthsLip purseFacial transplantationAssessment toolSound evidenceOutcomesNoseEyebrowsFacial Transplantation
Aycart M, Pomahac B. Facial Transplantation. DeckerMed Plastic Surgery 2018 DOI: 10.2310/ps.10073.Peer-Reviewed Original ResearchFacial transplantationMicrosurgical reconstructive techniquesShort-term resultsComposite tissue transplantationVascularized Composite AllotransplantationQuality of lifeConventional therapyFunctional outcomeTransplant surgeryLate outcomesReconstructive techniquesComposite allotransplantationTransplantationTissue transplantationNeck defectsClinical realityMedical communityRecipient evaluationImmunosuppressionCraniofacial surgerySurgeryComplex headOutcomesKey wordsMore experienceQuality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation
Oser M, Nizzi M, Zinser J, Turk M, Epstein R, Bueno E, Gitlin D, Pomahac B. Quality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2018, 59: 591-600. PMID: 29861176, DOI: 10.1016/j.psym.2018.04.005.Peer-Reviewed Original ResearchConceptsPhysical health QoLDepressive symptomsHealth statusPhysical health-related QoLFace transplantationOverall depressive symptomsHealth-related QoLMental health QOLSubthreshold depressive symptomsSevere facial disfigurementFacial transplantationQuality of lifeImmunosuppression inductionMonths posttransplantationDepressive episodePhysical QoLHigh health statusPatientsTransplantationQoLPsychosocial functioningLife outcomesCeiling effectsFacial disfigurementSymptoms
2017
The Effects of Lip-Closure Exercise on Lip Strength and Function Following Full Facial Transplantation: A Case Report
Perry B, Richburg B, Pomahac B, Bueno E, Green J. The Effects of Lip-Closure Exercise on Lip Strength and Function Following Full Facial Transplantation: A Case Report. American Journal Of Speech-Language Pathology 2017, 26: 682-686. PMID: 28654949, DOI: 10.1044/2017_ajslp-16-0101.Peer-Reviewed Original ResearchConceptsLip strengthFacial transplantationPatient-reported outcomesFull facial transplantationRange of motionStrength training exercisesSevere facial disfigurementPreliminary findingsExercise programAdditional researchCase reportOutcome measuresClinical measuresSingle patientMotor impairmentTransplantationClinical casesPatientsFacial disfigurementExerciseEfficacyNew optionsSpeech intelligibilityExpressionSwallowing
2016
Facial Transplantation
Aycart M, Alhefzi M, Kueckelhaus M, Fischer S, Dermietzel A, Wo L, Bueno E, Pribaz J, Pomahac B. Facial Transplantation. 2016, 5: 93-102. DOI: 10.1159/000444969.Peer-Reviewed Original ResearchAcute rejectionFacial transplantationDevastating facial injuriesPulse-dose corticosteroidsSolid organ transplantationThorough preoperative planningDonor pool expansionShort-term resultsPowerful clinical toolChronic rejectionDose corticosteroidsHost diseaseImmunomodulatory approachesGraft preservationCertain patientsFunctional outcomeOrgan transplantationFacial injuriesMultidisciplinary teamSensory functionClinical toolPatient safetyPreoperative planningPsychosocial outcomesTransplantationCodominant Role of Interferon‐γ– and Interleukin‐17–Producing T Cells During Rejection in Full Facial Transplant Recipients
Borges T, O'Malley J, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane J, Bueno E, Clark R, Tullius S, Chandraker A, Lian C, Murphy G, Strom T, Pomahac B, Najafian N, Riella L. Codominant Role of Interferon‐γ– and Interleukin‐17–Producing T Cells During Rejection in Full Facial Transplant Recipients. American Journal Of Transplantation 2016, 16: 2158-2171. PMID: 26749226, PMCID: PMC4979599, DOI: 10.1111/ajt.13705.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibody developmentDe novo donor-specific antibodiesInterleukin-17-producing T cellsT helper 2 cell phenotypeFacial transplantationDonor-specific antibody developmentNovo donor-specific antibodiesChemotactic protein-1 levelsPeripheral blood mononuclear cellsAcute cellular rejectionAnti-HLA antibodiesDonor-specific antibodiesFollicular helper cellsImmune cell subsetsProtein-1 levelsBlood mononuclear cellsMedium-term outcomesSkin biopsy specimensFull facial transplantationCellular rejection processLife-changing procedureCellular rejectionCodominant roleDonor alloreactivityTransplant recipients
2015
Facial transplantation
Wo L, Bueno E, Pomahac B. Facial transplantation. Current Opinion In Organ Transplantation 2015, Publish Ahead of Print: &na;. PMID: 26536422, DOI: 10.1097/mot.0000000000000253.Peer-Reviewed Original ResearchConceptsPositive HIV statusHIV statusFace transplantComposite allotransplantationUpper extremity transplantsDonor-specific antigensHistory of malignancyLatent viral infectionFacial transplantationChronic rejectionSimultaneous transplantationAbsolute contraindicationCase reportCurrent guidelinesFacial injuriesViral infectionTransplantTransplantationMedical teamAllotransplantationFirst face transplantFace transplantationFacial allotransplantationPatientsPsychological health
2014
Facial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients
2012
Psychosocial Changes 6 Months after Face Transplantation
Chang G, Pomahac B. Psychosocial Changes 6 Months after Face Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2012, 54: 367-371. PMID: 23194929, PMCID: PMC3593952, DOI: 10.1016/j.psym.2012.07.012.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultFacial TransplantationFemaleFollow-Up StudiesHumansInterpersonal RelationsInterview, PsychologicalLinear ModelsMaleOutcome Assessment, Health CarePostoperative PeriodPsychiatric Status Rating ScalesQuality of LifeSelf ConceptSurveys and QuestionnairesTime FactorsConceptsMental healthComprehensive psychiatric assessmentChanges 6 monthsCommon clinical practiceFull facial transplantationNovel surgical procedureMOS SF-12Facial transplantationOverall mental healthTransplantation programPsychosocial statusSurgical proceduresEQ-5D.Life measuresPsychiatric assessmentClinical practiceTransplantationPsychosocial changesFace transplantationMonthsRecipientsSurgeryMeasures 3Assessment protocolSame period
2011
Three Patients with Full Facial Transplantation
Pomahac B, Pribaz J, Eriksson E, Bueno E, Diaz-Siso J, Rybicki F, Annino D, Orgill D, Caterson E, Caterson S, Carty M, Chun Y, Sampson C, Janis J, Alam D, Saavedra A, Molnar J, Edrich T, Marty F, Tullius S. Three Patients with Full Facial Transplantation. New England Journal Of Medicine 2011, 366: 715-722. PMID: 22204672, DOI: 10.1056/nejmoa1111432.Peer-Reviewed Original ResearchConceptsFull face transplantFull facial transplantationFacial transplantationAcute rejectionPostoperative complicationsSensory nervesSevere deformityFunctional restorationPatientsSingle episodeFacial allograftTransplantationFacial appearanceConventional reconstructionComplicationsAllograftsNerveGlucocorticoidsTransplantDeformityCoaptationMonthsEvolution of indications for facial transplantation
Pomahac B, Diaz-Siso J, Bueno E. Evolution of indications for facial transplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2011, 64: 1410-1416. PMID: 21843979, DOI: 10.1016/j.bjps.2011.06.024.Peer-Reviewed Original ResearchConceptsLong-term outcomesFace transplantationUnknown long-term outcomesAbsolute exclusion criteriaInstitutional review board approvalExpansion of indicationsReview board approvalPartial face transplantationFacial transplantationFacial defectsEvolution of indicationsSevere facial defectsFacial functionLifelong immunosuppressionCurrent indicationsExclusion criteriaBoard approvalTransplantationSafe reductionSensory functionPatientsPotential patientsTransplantation studiesImmunosuppressionIndications
2008
Facial Transplantation and Immunosuppressed Patients: A New Frontier in Reconstructive Surgery
Pomahac B, Aflaki P, Chandraker A, Pribaz J. Facial Transplantation and Immunosuppressed Patients: A New Frontier in Reconstructive Surgery. Transplantation 2008, 85: 1693-1697. PMID: 18580458, DOI: 10.1097/tp.0b013e318176b29e.Peer-Reviewed Original ResearchConceptsPartial face transplantationOrgan transplant recipientsFace transplantationTransplant recipientsLife-long immunosuppressionPatient selection criteriaRisk of malignancyComposite tissue transplantationFacial transplantationAlternative reconstructive methodImmunosuppressive regimenImmunosuppressive therapyAdditional immunosuppressionSurgical resectionImmunosuppressed patientsOrgan recipientsPatient populationWomen's HospitalReconstructive surgeryTransplantationIRB approvalSkin cancerReconstructive methodsControversial procedureTissue transplantation