2024
Ten Year Follow-up After Face Transplantation – a Single Center Retrospective Cohort Study
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. Ten Year Follow-up After Face Transplantation – a Single Center Retrospective Cohort Study. American Journal Of Transplantation 2024 PMID: 39413877, DOI: 10.1016/j.ajt.2024.10.007.Peer-Reviewed Original ResearchChronic rejectionFace transplantationFollow-upSingle center retrospective cohort studyFunctional outcomesSensory returnAnalysis of functional outcomesMedian follow-upIncidence of malignancyMetabolic side effectsGraft rejection episodesComputed tomography angiogramRetrospective cohort studyEvidence of vasculopathyFollow-up periodLong-term outcomesYear follow-upFacial motor functionRejection episodesInfectious complicationsTransplant recipientsPatient ageGraft retentionMedical complicationsCohort studyAn Update on the Survival of the First 50 Face Transplants Worldwide
Homsy P, Huelsboemer L, Barret J, Blondeel P, Borsuk D, Bula D, Gelb B, Infante-Cossio P, Lantieri L, Mardini S, Morelon E, Nasir S, Papay F, Petruzzo P, Rodriguez E, Özkan Ö, Özmen S, Pomahac B, Lassus P. An Update on the Survival of the First 50 Face Transplants Worldwide. JAMA Surgery 2024, 159 PMID: 39292472, PMCID: PMC11411447, DOI: 10.1001/jamasurg.2024.3748.Peer-Reviewed Original ResearchOverall survivalRejection episodesFace transplantationTransplanted graftsMedian follow-up timeAcute rejection episodesFollow-up timePredictors of survivalMulticenter cohort studyExtensive facial defectsEpisodes per yearLong-term survivalTransplant variablesFacial defectsNonpublished dataTransplant lossMedian numberFollow-upCohort studyReconstructive optionsPrimary outcomeSecondary outcomesTransplant survivalTransplantationTransplant centersThe role of C4d and donor specific antibodies in face and hand transplantation—a systematic review
Huelsboemer L, Moscarelli J, Dony A, Boroumand S, Kochen A, Knoedler L, Yu C, Hauc S, Stögner V, Formica R, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The role of C4d and donor specific antibodies in face and hand transplantation—a systematic review. Frontiers In Transplantation 2024, 3: 1442006. PMID: 39291278, PMCID: PMC11405992, DOI: 10.3389/frtra.2024.1442006.Peer-Reviewed Original ResearchDonor-specific antibodiesSerum donor-specific antibodiesAntibody-mediated rejectionHigher rejection gradesVascularized composite allotransplantationC4d depositionRejection gradeCellular rejectionRejection episodesSpecific antibodiesDonor-specific antibody statusManagement of antibody-mediated rejectionFace transplantationAcute cellular rejectionAcute rejection episodesAssociated with high gradeTime of biopsyAntibody mediated rejectionFisher's exact testMann-Whitney U testSystematic review of electronic databasesMechanisms of rejectionSystematic reviewReview of electronic databasesC4d stainingImmunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failure
2023
Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review
Knoedler L, Knoedler S, Allam O, Remy K, Miragall M, Safi A, Alfertshofer M, Pomahac B, Kauke-Navarro M. Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review. Frontiers In Surgery 2023, 10: 1266399. PMID: 38026484, PMCID: PMC10646214, DOI: 10.3389/fsurg.2023.1266399.Peer-Reviewed Original ResearchComposite allotransplantationLong-term outcomesFacial trauma patientsSevere facial disfigurementRejection episodesSurgical treatmentTrauma patientsMalignancy screeningReconstructive surgeryClinical challengeFacial traumaPaucity of studiesReconstructive strategiesNarrative reviewPatientsFacial disfigurementAllotransplantationFuture studiesSurgeryDiagnosisTraumaDisfigurement
2022
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients
2019
Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation
Shubin A, Kollar B, Dillon S, Pomahac B, Libermann T, Riella L. Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation. Scientific Data 2019, 6: 314. PMID: 31819064, PMCID: PMC6901551, DOI: 10.1038/s41597-019-0324-y.Peer-Reviewed Original ResearchConceptsDevastating facial injuriesSevere rejection episodesAcute transplant rejectionType of transplantationPeripheral blood serumSOMAscan proteomics platformSatisfactory treatment optionAcute rejectionRejection episodesTransplant statusTransplantation centersTransplant rejectionTreatment optionsBiomarker discoverySkin biopsiesClinical dataHigh riskFacial injuriesInvasive biomarkersTransplantationAptamer-based technologiesFace transplantationPatientsBlood serumSerum proteinsThe Evolving Clinical Presentation of Acute Rejection in Facial Transplantation
Haug V, Kollar B, Obed D, Kiwanuka H, Turk M, Wo L, Tasigiorgos S, Kueckelhaus M, Riella L, Pomahac B. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 278-285. PMID: 30998810, PMCID: PMC6646986, DOI: 10.1001/jamafacial.2019.0076.Peer-Reviewed Original ResearchConceptsAcute rejectionSubtherapeutic tacrolimus levelsClinical signsRejection episodesImmunosuppressive therapySubclinical rejectionTacrolimus levelsMedical recordsOdds ratioFacial transplantationDiagnostic valueSignificant associationSingle-center cohort studyLate rejection episodesProtocol skin biopsiesSecond posttransplant yearSymptoms of rejectionTacrolimus blood levelsSecond postoperative yearReliable clinical signFull facial transplantationPostoperative yearPosttransplant yearYears posttransplantationAllograft rejection
2018
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantationPediatric face transplantation
Dorante M, Tasigiorgos S, Pomahac B. Pediatric face transplantation. Current Opinion In Organ Transplantation 2018, 23: 598-604. PMID: 30080696, DOI: 10.1097/mot.0000000000000572.Peer-Reviewed Original ResearchConceptsFace transplantationPediatric hand transplantationImmunosuppression burdenRejection episodesDonor allograftsPatient demographicsPediatric patientsAppropriate patientsHand transplantationHand transplantTransplantationPediatric colleaguesPatientsYoung populationFace transplantSurgical innovationTransplantOutcomes
2017
First Lower Two-Thirds Osteomyocutaneous Facial Allograft Perfused by a Unilateral Facial Artery
Fischer S, Lee T, Krezdorn N, Alhefzi M, Kueckelhaus M, Bueno E, Pomahac B. First Lower Two-Thirds Osteomyocutaneous Facial Allograft Perfused by a Unilateral Facial Artery. Plastic & Reconstructive Surgery 2017, 139: 1175e-1183e. PMID: 28445377, DOI: 10.1097/prs.0000000000003288.Peer-Reviewed Original ResearchConceptsFacial arteryFacial allograftImmunosuppressive therapyRejection episodesAirway volumeVenous outflowCLINICAL QUESTION/LEVELDual immunosuppressive therapyFacial allotransplantationTwo-thirdsMaintenance therapyMycophenolate mofetilSteroid pulseArtery anastomosisSurgical durationFacial functionTracheostomy tubeContralateral sideVascular anastomosisSubmental arteryTransplantationArteryAllograftsVascularization patternFacial form
2015
Utility of Sentinel Flaps in Assessing Facial Allograft Rejection
Kueckelhaus M, Fischer S, Lian C, Bueno E, Marty F, Tullius S, Pribaz J, Murphy G, Pomahac B. Utility of Sentinel Flaps in Assessing Facial Allograft Rejection. Plastic & Reconstructive Surgery 2015, 135: 250-258. PMID: 25255116, DOI: 10.1097/prs.0000000000000797.Peer-Reviewed Original ResearchConceptsFacial allograftRejection monitoringFasciocutaneous radial forearm flapCLINICAL QUESTION/LEVELSevere rejection episodesFurther surgical proceduresFacial allotransplantationFree fasciocutaneous radial forearm flapRadial forearm flapAxial blood supplyFunctional flapNonfacial sitesRejection episodesLimited skin areaSevere rejectionAllograft rejectionClinical findingsFacial dermatitisFrequent biopsiesBiopsy pairsBiopsy specimensHistologic evaluationSkin biopsiesBlood supplySurgical procedures
2014
Acute rejection in vascularized composite allotransplantation
Fischer S, Lian C, Kueckelhaus M, Strom T, Edelman E, Clark R, Murphy G, Chandraker A, Riella L, Tullius S, Pomahac B. Acute rejection in vascularized composite allotransplantation. Current Opinion In Organ Transplantation 2014, 19: 531-544. PMID: 25333831, DOI: 10.1097/mot.0000000000000140.Peer-Reviewed Original ResearchConceptsAcute rejection episodesAcute rejectionRejection episodesComposite allotransplantationDepth histological analysisHigh-dose steroidsLong-term safetyField of transplantationBetter diagnostic toolsFace transplant recipientsMaintenance immunosuppressionSteroid withdrawalTransplant recipientsCommon complicationImmunologic eventsAppropriate therapyPatient numbersTimely institutionRestorative surgeryDose reductionEarly diagnosisMost episodesNovel biomarkersHigh immunogenicityPatient careBiomarker evaluation of face transplant rejection: association of donor T cells with target cell injury
Lian C, Bueno E, Granter S, Laga A, Saavedra A, Lin W, Susa J, Zhan Q, Chandraker A, Tullius S, Pomahac B, Murphy G. Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury. Modern Pathology 2014, 27: 788-799. PMID: 24434898, DOI: 10.1038/modpathol.2013.249.Peer-Reviewed Original ResearchConceptsTarget cell injurySkin allograft rejectionDonor T cellsRecipient T cellsT cellsCell injuryAllograft rejectionMemory T cell subsetsAssessment of rejectionFacial transplantT cell subsetsPotential translational significanceImmune cell interactionsRejection episodesClinicopathological assessmentFollicular infundibulumHistologic evidenceSerial biopsiesTransplant rejectionEpidermal targetsDonor originImmune cellsSequential biopsiesDermal microvesselsTranslational significance
2011
Restoration of Facial Form and Function After Severe Disfigurement from Burn Injury by a Composite Facial Allograft
Pomahac B, Pribaz J, Eriksson E, Annino D, Caterson S, Sampson C, Chun Y, Orgill D, Nowinski D, Tullius S. Restoration of Facial Form and Function After Severe Disfigurement from Burn Injury by a Composite Facial Allograft. American Journal Of Transplantation 2011, 11: 386-393. PMID: 21214855, DOI: 10.1111/j.1600-6143.2010.03368.x.Peer-Reviewed Original ResearchConceptsSevere disfigurementMedical historyBurn injuryFacial allograftAcute rejection episodesInitial clinical outcomesElectrical burn injuryFacial allotransplantationSevere facial disfigurementDonor's medical historyAntirejection treatmentRejection episodesPostoperative monthSurgical complicationsClinical outcomesNasal breathingTreatment optionsBolus treatmentPathological analysisMinimal doseNormal social lifeEsthetic resultsSignificant restorationFacial formFacial redness