2010
A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules
Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmiercak B, Spiegel DA. A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules. ACS Chemical Biology 2010, 5: 1147-1155. PMID: 20923200, PMCID: PMC3003768, DOI: 10.1021/cb100195d.Peer-Reviewed Original ResearchConceptsCell wallCell wall engineeringCell-wall peptidoglycanWild-type bacteriaGram-positive bacterial pathogensPathogenic Gram-positive bacteriaStaphylococcus aureus cell wallBacterial cell wallBacterial cell surfaceEnzyme sortase ASmall moleculesGram-positive bacteriaWall peptidoglycanAureus cell wallMolecular handleBiosynthetic strategiesCell surfaceBacterial pathogensEndogenous levelsSortase AAzide-alkyne cycloaddition reactionChemical handlesWall engineeringBacteriaWidespread utilityA Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules
Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA. A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules. Journal Of The American Chemical Society 2010, 132: 12711-12716. PMID: 20726553, PMCID: PMC2965167, DOI: 10.1021/ja104591m.Peer-Reviewed Original Research
2009
Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer
Murelli RP, Zhang AX, Michel J, Jorgensen WL, Spiegel DA. Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer. Journal Of The American Chemical Society 2009, 131: 17090-17092. PMID: 19888723, PMCID: PMC2794306, DOI: 10.1021/ja906844e.Peer-Reviewed Original ResearchConceptsSmall moleculesFundamental chemical principlesBifunctional small moleculesProstate-specific membrane antigenProstate cancer cellsProstate cancerChemical principlesBiological evaluationCrystallographic dataMoleculesAmerican male populationTernary complexLNCaP human prostate cancer cellsCancer cellsHuman effector cellsHuman prostate cancer cellsCancer-related deathAntibody-dependent killingClasses of antibodiesHigh therapeutic potentialNovel classAntibody-recruiting moleculesHuman immune systemAnti-DNP antibodiesEffector cells