2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefits
2021
Exploring the impact of exercise and mind–body prehabilitation interventions on physical and psychological outcomes in women undergoing breast cancer surgery
Knoerl R, Giobbie-Hurder A, Sannes TS, Chagpar AB, Dillon D, Dominici LS, Frank ES, Golshan M, McTiernan A, Rhei E, Tolaney SM, Winer EP, Yung RL, Irwin ML, Ligibel JA. Exploring the impact of exercise and mind–body prehabilitation interventions on physical and psychological outcomes in women undergoing breast cancer surgery. Supportive Care In Cancer 2021, 30: 2027-2036. PMID: 34648061, DOI: 10.1007/s00520-021-06617-8.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsExerciseFemaleHumansMind-Body TherapiesPreoperative ExerciseQuality of LifeConceptsCancer treatment-related symptomsPrehabilitation interventionsTreatment-related symptomsTime of enrollmentImpact of exerciseQuality of lifeBreast cancerGroup participantsPre-operative exerciseBreast cancer surgeryMind-body interventionsCognitive functioningOpportunity trialCancer surgeryOutcome measuresSecondary analysisOne monthSurgeryMeasures of qualityGroup comparisonsCancer diagnosisCancerWomenInterventionSignificant differencesPhysical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance)
Ligibel JA, Huebner L, Rugo HS, Burstein HJ, Toppmeyer DL, Anders CK, Ma C, Barry WT, Suman V, Carey LA, Partridge AH, Hudis CA, Winer EP. Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance). JNCI Cancer Spectrum 2021, 5: pkab025-. PMID: 33981951, PMCID: PMC8103727, DOI: 10.1093/jncics/pkab025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBody HeightBody Mass IndexBody WeightBreast NeoplasmsEpothilonesExerciseFemaleHumansMiddle AgedObesityPaclitaxelProgression-Free SurvivalProportional Hazards ModelsTreatment OutcomeYoung AdultConceptsProgression-free survivalMetastatic breast cancerBody mass indexOverall survivalPhysical activityBreast cancerMass indexMET hoursFirst-line taxane-based chemotherapyHormone receptor-positive cancersBaseline body mass indexFirst-line chemotherapyTaxane-based chemotherapyReceptor-positive cancersRecreational physical activityRates of obesityMetastatic diseaseCox modelingMedian ageOverall mortalityRandomized trialsTask hoursMetabolic equivalentsPatientsCancer
2019
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
Ligibel JA, Dillon D, Giobbie-Hurder A, McTiernan A, Frank E, Cornwell M, Pun M, Campbell N, Dowling RJO, Chang MC, Tolaney S, Chagpar AB, Yung RL, Freedman RA, Dominici LS, Golshan M, Rhei E, Taneja K, Huang Y, Brown M, Winer EP, Jeselsohn R, Irwin ML. Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study. Clinical Cancer Research 2019, 25: 5398-5406. PMID: 31018921, DOI: 10.1158/1078-0432.ccr-18-3143.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCell ProliferationExerciseExercise TherapyFemaleHumansPreoperative CareConceptsPre-operative healthBreast cancerExercise interventionKi-67Exercise participantsLower cancer-specific mortalityPre-operative exercise interventionCancer-specific mortalityControl participantsBody mass indexTumor immune infiltratesImpact of exerciseBreast cancer proliferationMinutes/weekBreast cancer diagnosisOpportunity trialBaseline biopsiesImmune infiltratesMass indexSurgical excisionMean ageIntervention periodGene expressionChanges of expressionBreast tumors
2010
Physical and Psychological Outcomes Among Women in a Telephone-Based Exercise Intervention During Adjuvant Therapy for Early Stage Breast Cancer
Ligibel JA, Partridge A, Giobbie-Hurder A, Campbell N, Shockro L, Salinardi T, Winer EP. Physical and Psychological Outcomes Among Women in a Telephone-Based Exercise Intervention During Adjuvant Therapy for Early Stage Breast Cancer. Journal Of Women's Health 2010, 19: 1553-1559. PMID: 20629579, DOI: 10.1089/jwh.2009.1760.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerStage breast cancerExercise interventionBreast cancerWeight gainAdjuvant therapyHome-based exercise interventionModerate-intensity aerobic exercise interventionSingle-arm pilot studyIntensive chemotherapy regimensAerobic exercise interventionBreast cancer patientsActivity/weekBreast cancer recurrenceBreast cancer diagnosisAdjuvant chemotherapyChemotherapy regimensPostoperative complicationsSedentary womenWeek 12Cancer outcomesPoor QoLCancer patientsCardiorespiratory fitnessWeekly exercise
2009
Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors
Ligibel JA, Giobbie-Hurder A, Olenczuk D, Campbell N, Salinardi T, Winer EP, Mantzoros CS. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes & Control 2009, 20: 1523-1528. PMID: 19434504, DOI: 10.1007/s10552-009-9358-3.Peer-Reviewed Original ResearchConceptsHigh molecular weight adiponectinBreast cancer survivorsLevels of adiponectinMolecular weight adiponectinCancer survivorsExercise interventionWeight adiponectinOverweight breast cancer survivorsUsual care control groupEndurance exercise interventionCare control groupBreast cancer riskImpact of exerciseBody fat percentageAdipocytokine levelsExercise groupSignificant changesHip circumferenceMethodsOne hundredSignificant inverse relationshipBreast cancerAdiponectinCancer riskHip measurementsAnthropometric measurementsPhysical Activity Behaviors in Women with Newly Diagnosed Ductal Carcinoma-In-Situ
Ligibel JA, Partridge A, Giobbie-Hurder A, Golshan M, Emmons K, Winer EP. Physical Activity Behaviors in Women with Newly Diagnosed Ductal Carcinoma-In-Situ. Annals Of Surgical Oncology 2009, 16: 106-112. PMID: 18953612, PMCID: PMC5842912, DOI: 10.1245/s10434-008-0174-x.Peer-Reviewed Original ResearchConceptsPhysical activityDuctal carcinomaTreatment-related variablesLongitudinal cohort studyStrenuous physical activityBreast cancer riskLogistic regression modelingPhysical activity behaviorType of exerciseTamoxifen useCohort studyBilateral mastectomyEpidemiological evidenceSitu cancerReconstructive surgeryCancer riskDepressive symptomsExercise levelsMost womenExercise frequencyHealth outcomesActivity behaviorWomenExercise behaviorNonsignificant variables
2008
Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors
Ligibel JA, Campbell N, Partridge A, Chen WY, Salinardi T, Chen H, Adloff K, Keshaviah A, Winer EP. Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors. Journal Of Clinical Oncology 2008, 26: 907-912. PMID: 18281663, DOI: 10.1200/jco.2007.12.7357.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsExercise groupCancer survivorsInsulin levelsExercise interventionInsulin concentrationsGlucose levelsBody compositionControl groupOverweight breast cancer survivorsUsual care control groupEndurance exercise interventionCare control groupMicroU/mLSignificant decreaseBreast cancer recurrenceBreast cancer riskBreast cancer prognosisInsulin resistanceHip circumferenceCancer recurrenceBody fatHip measurementsPhysical activityCancer risk
2001
Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy.
Demark-Wahnefried W, Peterson B, Winer E, Marks L, Aziz N, Marcom P, Blackwell K, Rimer B. Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. Journal Of Clinical Oncology 2001, 19: 2381-9. PMID: 11331316, DOI: 10.1200/jco.2001.19.9.2381.Peer-Reviewed Original ResearchConceptsBreast cancer patientsCancer patientsPhysical activityWeight gainAdjuvant chemotherapySarcopenic obesityCT groupBody compositionPremenopausal breast cancer patientsOperable breast carcinomaReduced physical activityLeg lean massLean body massSignificant differencesLT patientsPremenopausal womenYears postdiagnosisDietary intakeFat massResistance trainingBreast carcinomaMean changeLean massBody fatChemotherapy
1997
Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy
Demark-Wahnefried W, Hars V, Conaway, Havlin K, Rimer B, McElveen G, Winer E. Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. American Journal Of Clinical Nutrition 1997, 65: 1495-1501. PMID: 9129482, DOI: 10.1093/ajcn/65.5.1495.Peer-Reviewed Original ResearchConceptsBreast cancer patientsAdjuvant chemotherapyCancer patientsPhysical activityEnergy intakeWeight gainBreast cancerBody compositionCompletion of chemotherapyCommon side effectsCourse of therapyDiet-induced thermogenesisQuality of lifePremenopausal patientsLeucovorin chemotherapyChemotherapySide effectsStage IBaseline levelsPatientsImpairs survivalEnergy expenditureOptimal interventionIntakeComplete data